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Brain tumor evaluation using /sup 82/Rb and positron emission tomography

Journal Article · · J. Nucl. Med.; (United States)
OSTI ID:6816842
; ; ; ; ; ;
Positron emission tomography of the brain with 75-sec rubidium-82 obtained from a portable generator (25-day /sup 82/Sr leads to /sup 82/Rb) was used to evaluate the integrity of the blood-brain barrier (BBB) in patients with brain tumors. Rubidium is normally excluded from the central nervous system by the intact BBB, but when the BBB is disrupted by a tumor. Rb enters and pools in the extravascular spaces of the central nervous system. Since Rb is also rapidly cleared from the blood, a high tissue-to-blood ratio of the /sup 82/Rb tracer is achieved in regions of BBB disruption after intravenous injection. With dynamic positron emission tomographic imaging, the extravasation of the Rb tracer can be evaluated independent of the intravascular Rb concentration, and very small changes in the BBB permeability can be detected. The results of our studies in eight patients show that this technique is a promising method for evaluation of the BBB integrity in brain-tumor patients.
Research Organization:
University of California, Berkeley
OSTI ID:
6816842
Journal Information:
J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 23:6; ISSN JNMEA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALKALI METAL ISOTOPES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLOOD-BRAIN BARRIER
BLOOD-PLASMA CLEARANCE
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CLEARANCE
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOTOPES
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANS
PATIENTS
PHYSIOLOGY
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPE SCANNING
RADIOISOTOPES
RUBIDIUM 82
RUBIDIUM ISOTOPES
SCINTISCANNING
TOMOGRAPHY
USES