A study of the FDG model in the presence of an altered blood brain barrier (BBB) and glucose metabolic/flow relationships in human brain tumors with PET

Conference · Wed May 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:6760748

Hawkins, R A; Phelps, M E; Huang, S C; Wapenski, J A; Silberman, A W

The authors performed 3 hour kinetic FDG studies (5 parameter model, 5th parameter represents cerebral blood volume (CBV) on 8 patients with primary or metastatic brain tumors. One subject also had a direct measurement of BBB permeability with Ga-68 EDTA and 5 subjects also had cerebral blood flow (CBF) determinations with bolus injections of 0-15 water. Estimates of hexose distribution volumes (HDV=k/sub 1/*/k/sub 2/*), FDG distribution volumes (DV=k/sub 1/*/(k/sub 2/*+k/sub 3/*), a ratio R=k/sub 3/*k/sub 2/* that is related to the stability of the lumped constant (LC) and glucose extraction ratios (GER) were calculated. GER averaged 8.8 (+- 4.6)% in tumors, 7.7 (+- 1.7)% in gray matter, 10.3 (+- 3.8)% in white matter and 8.4 (+- 2.1)% in hemispheric regions. R averaged 0.46 (+- 0.19) in tumors, 0.47 (+- 0.24) in gray matter, 0.45 (+- 0.18) in white matter and 0.57 (+- 0.25) in hemispheric regions. HDV estimates were 0.33 (+- 0.11) in tumors, 0.48 (+- 0.25) in gray matter, 0.34 (+- 0.14) in white matter and 0.38 (+- 0.25) in hemispheric regions. DV estimates were smaller than HDV but were not significantly different over the same groups. These results suggest that the compartmental configuration of the FDG model is still appropriate in this set of patients with increased BBB permeability and that LC is relatively stable. A lack of significant increase in the FDG rate constants k/sub 1/* and k/sub 2/* with increases BBB permeability suggests that facilitated diffusion remains the dominant mechanism of glucose transport even with BBB abnormalities.

• Research Organization: UCLA School of Medicine, Los Angeles, CA
• OSTI ID: 6760748
• Report Number(s): CONF-850611-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
ANTIMETABOLITES
BLOOD FLOW
BLOOD-BRAIN BARRIER
BODY
BRAIN
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
CHEMICAL REACTION KINETICS
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
DYNAMIC FUNCTION STUDIES
EMISSION COMPUTED TOMOGRAPHY
FLUORODEOXYGLUCOSE
GLUCOSE
HEXOSES
KINETICS
LABELLING
MATHEMATICAL MODELS
METABOLISM
MONOSACCHARIDES
NEOPLASMS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PERMEABILITY
POSITRON COMPUTED TOMOGRAPHY
RADIONUCLIDE KINETICS
REACTION KINETICS
SACCHARIDES
TOMOGRAPHY