The use of /sup 11/C-glucose and positron emission tomography to measure brain glucose metabolism

Conference · Wed May 01 00:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:6795584

Mintun, M A; Raichle, M E; Welch, M J; Kilbourn, M R

To measure regional cerebral metabolism of glucose (CMRGlu) with positron emission tomography (PET), but avoid the potential problems inherent in the use of /sup 18/F-fluoro-deoxyglucose, (e.g. regional variation in regional rate constants and instability of the ''lumped constant''), the authors have developed a method using uniformly labeled /sup 11/C-glucose. The method employs a 4-compartment model that accounts for vascular tracer, transport of tracer in and out of the extravascular space, metabolism of tracer, and the production of labeled carbon dioxide, which is free to leave the tissue with blood flow. The differential equations for this model, when solved for CMRGlu, yield CMRGlu=k/sub 1/ . k/sub 3/ . CBF . C/sub B//(k/sub 1/ . k/sub 3/+CBF/CBV . (k/sub 2/+k/sub 3/)) where CBF and CBV are cerebral blood flow and volume, C/sub B/ is unlabeled blood glucose content, k/sub 1/ and k/sub 2/ are transport rate constants and k/sub 3/ is the metabolism rate constant. The authors have begun implementing this technique in baboons and human subjects by first measuring regional CBV and CBF with extant PET methods, then after injection of 20-40mCi of U-/sup 11/C-glucose, estimating the rate constants from 40 sequential PET scans taken over 20 minutes. Resulting white-to-gray matter range in CMRGlu for one typical human subject was 2.9 to 6.3 mg/(min . 100 mg). Oxygen metabolism (CMRO/sub 2/) was also measured at the same sitting with PET and the molar ratio of CMRO/sub 2//CMRGlu ranged from 5.8 to 6.4 as would be expected. These results demonstrate that it may be feasible to avoid the difficulties of an analogue tracer in the measurement of CMRGlu by using /sup 11/C-glucose.

• Research Organization: Washington Univ. School of Medicine, St. Louis, MO
• OSTI ID: 6795584
• Report Number(s): CONF-850611-; TRN: 87-010638
• Journal Information: J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
• Country of Publication: United States
• Language: English

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GLUCOSE
LABELLING
CARBON 11
LABELLED COMPOUNDS
RADIONUCLIDE KINETICS
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CENTRAL NERVOUS SYSTEM
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DIAGNOSTIC TECHNIQUES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
HEXOSES
ISOTOPES
LIGHT NUCLEI
MINUTES LIVING RADIOISOTOPES
MONOSACCHARIDES
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NUCLEI
ORGANIC COMPOUNDS
ORGANS
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SACCHARIDES
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550601* - Medicine- Unsealed Radionuclides in Diagnostics