Brain oxygen utilization measured with O-15 radiotracers and positron emission tomography

Journal Article · Wed Feb 01 04:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:5242639

Mintun, M A ^[1]; Raichle, M E; Martin, W R.W.; Herscovitch, P

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1. Edward Mallinckrodt Inst. of Radiology, St. Louis, MO

The authors have developed, implemented, and validated a method for the measurement of the local cerebral metabolic rate for oxygen (CMRO/sub 2/) with positron emission tomography (PET). They use data from a single inhalation of O-15-labeled CO for cerebral blood volume (CBV), an intravenous injection of (O-15)H/sub 2/O for cerebral blood flow (CBF), and a single inhalation of (O-15)O/sub 2/ for the final calculation of CMRO/sub 2/ and the extraction of oxygen (E). The mathematical model used to analyze the data consists of two compartments and accounts for production and egress of water of metabolism in the tissue, recirculating water of metabolism and the arterial, venous, and capillary contents of (O-15)O/sub 2/ in the brain. The authors validated their technique in baboons by comparing the PET-measured E with E measured using an intracarotid injection of (O-15)O/sub 2/. The correlation between these two techniques was excellent. The technique was implemented on five normal human subjects.

• OSTI ID: 5242639
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 25:2; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

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550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
APES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
BRAIN
CARBON COMPOUNDS
CARBON MONOXIDE
CARBON OXIDES
CENTRAL NERVOUS SYSTEM
CHALCOGENIDES
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
ELEMENTS
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
INHALATION
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOTOPES
LIGHT NUCLEI
MAMMALS
MATHEMATICAL MODELS
METABOLISM
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NONMETALS
NUCLEI
ORGANS
OXIDES
OXYGEN
OXYGEN 15
OXYGEN COMPOUNDS
OXYGEN ISOTOPES
POSITRON COMPUTED TOMOGRAPHY
PRIMATES
RADIOISOTOPES
TOMOGRAPHY
VERTEBRATES
VOLUME