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Effect of tissue heterogeneity on the measurement of regional cerebral oxygen extraction (E) and metabolic rate (CMRO/sub 2/) with positron emission tomography

Conference · · J. Nucl. Med.; (United States)
OSTI ID:5936454
;
Methods for measuring cerebral blood flow (CBF) and oxygen metabolism with PET assume local tissue homogeneity. However, because of limited spatial resolution, a region of interest (ROI) will include tissue count contributions from both gray matter (GM) and white matter (WM). This assumes importance because the PET measurement in such a ROI may not equal the true weighted local E or CMRO/sub 2/ due to nonlinearities in the tracer model. The authors simulated the effect of tissue heterogeneity on the accuracy of two methods to measure E and CMRO/sub 2/, the steady-state method (J CBF Metab 3:416, 1983) and the bolus inhalation method (J Nucl Med 25:177, 1984). The simulation included the potential for heterogeneity in CBF, CMRO/sub 2/, blood volume, and tracer partition coefficient. With the bolus inhalation method, the error in E was <2%, and in CMRO/sub 2/, -2 to -7%. In both methods, the error was greater in cases with higher local CBF. The greater errors in CMRO/sub 2/ with the steady state method were due to large underestimations in CBF in heterogeneous regions with this method. An understanding of the effects of tissue heterogeneity is important in using these methods to measure E and CMRO/sub 2/ with PET.
Research Organization:
Washington Univ. School of Medicine, St. Louis, MO
OSTI ID:
5936454
Report Number(s):
CONF-850611-
Conference Information:
Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
Country of Publication:
United States
Language:
English

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Related Subjects

550501 -- Metabolism-- Tracer Techniques
550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ACCURACY
BASAL METABOLISM
BIOCHEMICAL OXYGEN DEMAND
BLOOD FLOW
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
COMPUTERIZED SIMULATION
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
EMISSION COMPUTED TOMOGRAPHY
IMAGE PROCESSING
MATHEMATICAL MODELS
MEMBRANE TRANSPORT
METABOLISM
NERVOUS SYSTEM
ORGANS
POSITRON COMPUTED TOMOGRAPHY
PROCESSING
SIMULATION
TOMOGRAPHY