Positron imaging of intravenous O-15 labeled water for cerebral blood flow
The purpose of this work was the development of a new technique for the determination of LCBF using the continuous, intravenous infusion of 0-15 H20 and PET imaging. Eight normal human subjects were studied. During a 20-30 min infusion, multiple arterial blood samples were withdrawn for a PaCO/sub 2/ and 0-15 concentration measurement. PET imaging commenced 8-12 minutes after the infusion was started. CBF was determined by using the equilibrium model or, when appropriate, a non-equilibrium CBF model which permitted the arterial 0-15 concentration to change with time. In contrast to the equilibrium model, this model uses the actual arterial time course as the input function. Whole brain CBF was determined with an average brain-blood partition coefficient of 0.96 ml/g. Corrections were made for tissue heterogeneity and for the loss of counts from the whole brain region of interest (ROI). Regional CBF values were generated by selecting ROI's in predominantly gray or white matter areas using an atlas overlay system and actual brain-blood partition coefficients of 0.88 and 1.05 ml/g for white and gray matter, respectively. The mean whole brain CBF for 9 measurements in 8 subjects was 57 ml/min/100g (SD 11) corrected to a normal PaCO/sub 2/ of 40 mmHg. In comparison to techniques employing 0-15 CO/sub 2/ inhalation, the advantages of the continuous infusion technique are low radiation dose to the lung and ease of tracer administration in patients who will not tolerate inhalation. In addition, PET instruments with low count rate capabilities can be used. The new, non-equilibrium CBF model permits arterial curve changes with time and enables imaging to be started before equilibrium.
- Research Organization:
- Univ. of Pennsylvania, Philadelphia, PA
- OSTI ID:
- 6843249
- Report Number(s):
- CONF-840619-
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 25:5; Conference: 31. annual meeting of the Society of Nuclear Medicine, Los Angeles, CA, USA, 5 Jun 1984
- Country of Publication:
- United States
- Language:
- English
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550602* - Medicine- External Radiation in Diagnostics- (1980-)
550601 - Medicine- Unsealed Radionuclides in Diagnostics