Cerebral blood flow with the continuous infusion of oxygen-15-labeled water
This work describes the determination of CBF in eight normal human subjects with positron emission tomographic (PET) imaging using the continuous intravenous infusion of H2(15)O. A whole-brain CBF model is described that permits the comparison of the CBF values determined using PET with those obtained using other methods. This model includes a correction for whole-brain recovery coefficient, a correction for the underestimation of flow due to the nonlinearity of the CBF model when considering tissue that includes both gray and white matter, the use of in vitro-determined brain-blood partition coefficients for gray and white matter, and a variation of the equilibrium model that permits the arterial concentration to vary. CBF values using this method compare well with values determined previously. Regional determinations using a brain overlay atlas are presented. Radiation dosimetry for the continuous infusion of H2(15)O is also included.
- Research Organization:
- Univ. of Pennsylvania, Philadelphia, PA (United States)
- OSTI ID:
- 6179606
- Journal Information:
- J. Cereb. Blood Flow Metab.; (United States), Vol. 4
- Country of Publication:
- United States
- Language:
- English
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BRAIN
BLOOD FLOW
BIOLOGICAL MODELS
BLOOD CIRCULATION
EMISSION COMPUTED TOMOGRAPHY
MAN
OXYGEN 15
POSITRONS
RADIATION DOSES
TRACER TECHNIQUES
WATER
ANIMALS
ANTILEPTONS
ANTIMATTER
ANTIPARTICLES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DOSES
ELEMENTARY PARTICLES
EVEN-ODD NUCLEI
FERMIONS
HYDROGEN COMPOUNDS
ISOTOPE APPLICATIONS
ISOTOPES
LEPTONS
LIGHT NUCLEI
MAMMALS
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANS
OXYGEN COMPOUNDS
OXYGEN ISOTOPES
PRIMATES
RADIOISOTOPES
TOMOGRAPHY
VERTEBRATES
551001* - Physiological Systems- Tracer Techniques