Nuclear medicine technology progress report for quarter ending June 30, 1980

Technical Report · Thu Jan 01 04:00:00 EST 1981

DOI:https://doi.org/10.2172/7064407· OSTI ID:7064407

Results of experiments demonstrated that the alkyl portion of 9-telluraheptadecanoic acid (9-THDA) is retained in the myocardial tissue of rats to the same extent as radioactivity from /sup 123m/Te-9-THDA. Tissue distribution experiments in rats one hr after injection of 10-(/sup 14/C)-9-telluraheptadecanoic acid were compared with the results of a parallel study using /sup 123m/Te-9-THDA. The results indicate that the alkyl region of 9-THDA is retained in the myocardium and that labeling of this portion of the 9-THDA molecule with radiohalogens such as /sup 123/I may be an attractive approach for evaluation of myocardial function. Results of preliminary studies for the development of radiolabeled barbiturates as a new class of agents for the measurement of regional blood perfusion in the brain are also described. Several new barbiturates substituted at the C-5 position were prepared and characterized. These compounds will be labeled with /sup 117m/Sn, /sup 75/Se, and /sup 123m/Te and brain uptake studies performed in rats. Studies of arsenic trioxide (As/sub 2/O/sub 3/) toxicity for human cells in the diffusion chamber assay system have continued. Studies employing /sup 74/As/sub 2/O/sub 3/ have demonstrated that uptake of radioactivity from test substances administered to rats can be detected in cells taken from the intraperitoneally-implanted diffusion chambers. Preliminary synthetic studies of gold-based antirheumatoid complexes are also reported. Several /sup 11/C-labeled amino acids have been prepared for clinical testing. Platinum-195m-labeled-cis-dichlorodiammine-platinum(II) was supplied to collaborators for further testing and /sup 75/Se- and /sup 123m/Te-labeled long-chain fatty acids were supplied to several medical investigators for the evaluation of myocardial function in experimental animals. (ERB)

• Research Organization: Oak Ridge National Lab., TN (USA)
• Sponsoring Organization: USDOE
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 7064407
• Report Number(s): ORNL/TM-7482
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702 -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
551001 -- Physiological Systems-- Tracer Techniques
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
ARSENIC COMPOUNDS
ARSENIC ISOTOPES
ARSENIC OXIDES
AZINES
BARBITURATES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BODY
CARBON 11
CARBON ISOTOPES
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
CHALCOGENIDES
CHEMICAL PREPARATION
COMPLEXES
DAYS LIVING RADIOISOTOPES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
FUNCTIONS
GOLD COMPLEXES
HEART
HEAVY NUCLEI
HETEROCYCLIC COMPOUNDS
HYPNOTICS AND SEDATIVES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MATERIALS
MINUTES LIVING RADIOISOTOPES
MONOCARBOXYLIC ACIDS
MUSCLES
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PLATINUM 195
PLATINUM COMPLEXES
PLATINUM ISOTOPES
PYRIMIDINES
RADIOACTIVE MATERIALS
RADIOISOTOPES
RADIOPHARMACEUTICALS
RODENTS
SECONDS LIVING RADIOISOTOPES
SELENIUM 75
SELENIUM ISOTOPES
SKELETAL DISEASES
STABLE ISOTOPES
SYNTHESIS
TELLURIUM 123
TELLURIUM COMPOUNDS
TELLURIUM ISOTOPES
TESTING
THERAPY
TIN 117
TIN ISOTOPES
TOXICITY
TRANSITION ELEMENT COMPLEXES
VERTEBRATES