Nuclear medicine technology. Progress report for quarter ending September 30, 1979
Adrenal uptake in rats of /sup 117m/Sn-labeled 23-(trimethyl stanna)-24-nor-5..cap alpha..-cholan-3..beta..-o1 is demonstrated. The adrenal:blood and adrenal:liver ratios were 33:1 and 9:1, only one day after intravenous administration. A variety of /sup 117m/Sn-labeled steroids with structural modifications were also prepared to determine their effects on the adrenal uptake of these unusual steroids. Structural features required for significant adrenal uptake were determined. The diffusion chamber assay system has been assessed as a means of investigating the toxicity and biological fate of trace elements from energy technologies. In a preliminary experiment, the cell population in chambers from rats exposed to As/sub 2/O/sub 3/ was inhibited 48% one day after treatment. The results of continuing studies with /sup 75/Se, /sup 11/C, and /sup 195m/Pt-labeled agents are also described. Several /sup 75/Se-labeled long-chain fatty acids were prepared to determine heart uptake. Selenium-75-labeled 9-selenapentacosanoic acid showed the highest uptake of the compounds investigated. Preliminary radiation dose estimates have been performed for several /sup 75/Se and /sup 123m/Te-labeled fatty acids. Tissue distribution and excretion data for /sup 75/Se-labeled 9-selenaheptadecanoic acid and /sup 123m/Te-labeled 9-telluraheptadecanoic acid indicate that the human liver would recieve the highest absorbed radiation dose.Tissue distribution studies in rats with a series of /sup 195m/Pt-labeled chloroammine complexes have demonstrated that the tissue distribution and excretion characteristics of the chlorcammine complexes closely parallel their physicochemical properties. Further patient studies have assessed the efficacy of emission computerized tomographic organ imaging with /sup 11/C-valine, and /sup 11/C-amino-cyclobutanecarboxylic acid (ACBC). (ERB)
- Research Organization:
- Oak Ridge National Lab., TN (USA)
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 5545574
- Report Number(s):
- ORNL/TM-7072
- Country of Publication:
- United States
- Language:
- English
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Nuclear medicine technology progress report for quarter ending June 30, 1979
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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL GLANDS
AMINO ACIDS
AMMINES
ANIMAL CELLS
ANIMALS
ARSENIC COMPOUNDS
ARSENIC OXIDES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL LOCALIZATION
BODY
CARBON 11
CARBON ISOTOPES
CARBOXYLIC ACID ESTERS
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CAT SCANNING
CHALCOGENIDES
CHEMICAL PREPARATION
CLEARANCE
CLOUD CHAMBERS
COMPLEXES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISTRIBUTION
DOSES
DOSIMETRY
DRUGS
ECAT SCANNING
ELECTRON CAPTURE RADIOISOTOPES
EMBRYONIC CELLS
ENDOCRINE GLANDS
ESTERS
EVEN-ODD NUCLEI
EXCRETION
GAS TRACK DETECTORS
GLANDS
GROWTH
HEART
HEAVY NUCLEI
INTAKE
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
LIVER
MAMMALS
MEASURING INSTRUMENTS
MINUTES LIVING RADIOISOTOPES
MUSCLES
MYOCARDIUM
NUCLEI
ORGANIC ACIDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PHOTON EMISSION SCANNING
PHOTON TRANSMISSION SCANNING
PLATINUM 195
PLATINUM COMPLEXES
PLATINUM ISOTOPES
RADIATION DETECTORS
RADIATION DOSES
RADIOACTIVE MATERIALS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
RODENTS
SELENIUM 75
SELENIUM ISOTOPES
STABLE ISOTOPES
STEROIDS
SYNTHESIS
TELLURIUM 123
TELLURIUM ISOTOPES
TIN 117
TIN ISOTOPES
TISSUE DISTRIBUTION
TOMOGRAPHY
TRANSITION ELEMENT COMPLEXES
VALINE
VERTEBRATES