Health and safety research division. Nuclear medicine technology progress report for period ending March 31, 1979
The preparation of a unique class of trimethyltin-substituted steroids is described that were designed because of the potential use of the /sup 117m/Sn-labeled analogs for adrenal imaging. The trimethyltin-substituted steroids were readily prepared on the microscale in yields ranging from 40 to 80%. Studies with the /sup 123m/Te-labeled fatty acids have continued, and radiolabeled 6-telluraheptadecanoic acid and 11-telluraheptadecanoic acid have shown pronounced heart uptake in rats. These results suggest that the position of the tellurium heteroatom has little effect on the heart uptake of the telluraheptadecanoic acids. Interest in the potential use of /sup 73/Se-labeled agents for tomographic imaging applications has resulted in the preparation of several /sup 75/Se-labeled compounds for preliminary tissue distribution studies in rats. Significant heart uptake was observed with /sup 75/Se-labeled-9-selenoheptadecanoic acid, suggesting that the various structural features affecting heart uptake of seleno fatty acids should also be explored. In addition, /sup 75/Se-labeled 24-(isopropyl seleno)-chol-5-en-3..beta..-ol was prepared and showed pronounced adrenal uptake in rats. The results of continuing studies with /sup 11/C-labeled amino acids in a collaborative project with the Oak Ridge Associated Universities (ORAU) are also described. Recent patient studies at ORAU have established that /sup 11/C-DL-tryptophan is superior to /sup 11/-DL-valine for pancreatic visualization by positron emission tomography. Nitrogen-13 was prepared for the first time in the ORNL 86-inch cyclotron and converted to /sup 13/N-ammonia that was used successfully to visualize dog hearts. (ERB)
- Research Organization:
- Oak Ridge National Lab., TN (USA)
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 5932686
- Report Number(s):
- ORNL/TM-6916
- Country of Publication:
- United States
- Language:
- English
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Nuclear medicine technology progress report for quarter ending December 31, 1979
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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL GLANDS
ALCOHOLS
AMINO ACIDS
AMMONIA
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BODY
CARBON 11
CARBON ISOTOPES
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CHEMICAL PREPARATION
COUNTING TECHNIQUES
DATA
DATA FORMS
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
GLANDS
HEART
HYDRIDES
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOLATED VALUES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE PRODUCTION
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MINUTES LIVING RADIOISOTOPES
MONOCARBOXYLIC ACIDS
NITROGEN 13
NITROGEN COMPOUNDS
NITROGEN HYDRIDES
NITROGEN ISOTOPES
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PANCREAS
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
RATS
RODENTS
SCINTISCANNING
SELENIUM 75
SELENIUM COMPOUNDS
SELENIUM ISOTOPES
STABLE ISOTOPES
STEROIDS
SYNTHESIS
TELLURIUM 123
TELLURIUM ISOTOPES
TIN 117
TIN ISOTOPES
TISSUE DISTRIBUTION
VERTEBRATES