Nuclear medicine technology progress report for quarter ending December 31, 1979

Technical Report · Tue Apr 01 04:00:00 EST 1980

DOI:https://doi.org/10.2172/5389811· OSTI ID:5389811

Knapp, Jr., F. F.

Platinum-195m-labeled cis-dichloro-trans-dihydroxy-bis-(isopropylamine)-platinum(IV) (CHIP) was prepared for the first time. This second-generation platinum antitumor agent appears superior to the widely used cis-dichloro-diammineplatinum(II) (cis-DDP) since the dose-limiting nephrotoxicity associated with cis-DDP therapy is not encountered. Platinum-195m-labeled CHIP is being used to determine the tissue-distribution, excretion, and other pharmacological properties of this new drug. Studies of the heart uptake in rats of /sup 75/Se and /sup 123m/Te-labeled long-chain fatty acids have continued. The greater heart uptake of /sup 123m/Te-9-telluraheptadecanoic acid compared with the selenium analog, /sup 75/Se-9-selenaheptadecanoic acid, was confirmed. Radiation dose estimates for a new adrenal imaging agent, /sup 117m/Sn-23-(trimethylstanna)-24-nor-5..cap alpha..-cholan-3..beta..-ol (23-TSC) have been completed. Tissue distribution and excretion data for /sup 117m/Sn-23-TSC were used to extrapolate the radiation dose values to humans. The calculated radiation dose values for /sup 117m/Sn-23-TSC are: adrenals, 83 rads/mCi; total body, 0.77 rad/mCi/; and ovaries, 4.4 rads/mCi. These values are considerably lower than similar estimates for a variety of other radiolabeled steroids and suggest that /sup 117m/Sn-23-TSC may be an attractive new agent for adrenal visualization in humans. The diffusion chamber assay system has been further assessed as a technique to determine the toxicity of As/sub 2/O/sub 3/ administration on the proliferation of cells within chambers implanted in the peritoneal cavities of rats and hamsters. Both human embryonic lung cells and human nasopharyngeal carcinoma cells were used in the studies.

• Research Organization: Oak Ridge National Lab., TN (USA)
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 5389811
• Report Number(s): ORNL/TM-7223
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702 -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
560171 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Man-- (-1987)
560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
560301 -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL GLANDS
AMINES
AMINO ACIDS
ANIMAL CELLS
ANIMALS
ARSENIC COMPOUNDS
ARSENIC OXIDES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL LOCALIZATION
BODY
BRAIN
CARBON 11
CARBON ISOTOPES
CARBOXYLIC ACID ESTERS
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CELL PROLIFERATION
CENTRAL NERVOUS SYSTEM
CHALCOGENIDES
CHEMICAL PREPARATION
CLEARANCE
COMPLEXES
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
DOSES
DOSIMETRY
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMBRYONIC CELLS
EMISSION COMPUTED TOMOGRAPHY
ENDOCRINE GLANDS
ESTERS
EVEN-ODD NUCLEI
EXCRETION
FEMALE GENITALS
GLANDS
GONADS
HEART
HEAVY NUCLEI
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
LUNGS
MAMMALS
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NERVOUS SYSTEM
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OVARIES
OXIDES
OXYGEN COMPOUNDS
PANCREAS
PHARMACOLOGY
PHOTON EMISSION SCANNING
PLATINUM 195
PLATINUM COMPLEXES
PLATINUM ISOTOPES
RADIATION DOSES
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
RESPIRATORY SYSTEM
RODENTS
SCINTISCANNING
SELENIUM 75
SELENIUM ISOTOPES
STABLE ISOTOPES
STEROIDS
SYNTHESIS
TELLURIUM 123
TELLURIUM COMPLEXES
TELLURIUM ISOTOPES
TIN 117
TIN ISOTOPES
TISSUE DISTRIBUTION
TOMOGRAPHY
TOXICITY
TRANSITION ELEMENT COMPLEXES
TUMOR CELLS
VERTEBRATES