Nuclear medicine technology. Progress report, quarter ending March 31, 1980

Technical Report · Wed Oct 01 04:00:00 EDT 1980

DOI:https://doi.org/10.2172/6773915· OSTI ID:6773915

Knapp, Jr., F. F.

The successful detection of experimentally produced myocardial infarctions in rats and dogs using /sup 123m/Te-9-telluraheptadecanoic acid (9-(/sup 123m/Te)-THDA) is described. Preferential localization of radioactivity in normal myocardial tissue of rats that had experimentally produced infarctions was also demonstrated by tissue distribution studies following injection of 9-(/sup 123m/Te)-THDA. The effects of chain length on the myocardial uptake of /sup 75/Se-labeled long-chain fatty acids was also studied further. Selenium-75-labeled 13-selenaheneicosonic acid (H/sub 3/C-(CH/sub 2/)/sub 7/-/sup 75/Se-(CH/sub 2/)/sub 11/-COOH, 13-(/sup 75/Se)-SHCA) shows the highest heart uptake in rats of the agents studied. These results indicate that myocardial imaging may be possible with 13-(/sup 75/Se)-SHCA and also suggest that potential positron emission tomography of the myocardium with the /sup 73/Se-labeled agent should be explored. The results of continuing studies with /sup 11/C and /sup 195m/Pt-labeled agents are also described. A variety of /sup 11/C-labeled amino acids were prepared and tested as pancreas and tumor localizing agents in a Medical Cooperative Program with the Oak Ridge Associated Universities. The microscale synthesis of /sup 195m/Pt-labeled cis-dichloro-trans-dihydroxy-bis-(isopropylamine)platinum(IV) (/sup 195m/Pt-CHIP) was developed further and preliminary tissue distribution studies with this important second-generation antitumor drug were completed in rats. Platinum-195m-labeled cis-dichlorodiammineplatinum(II) (/sup 195m/Pt-cis-DDP) was supplied for testing to a number of Medical Cooperative Programs. Studies of arsenic trioxide (As/sub 2/O/sub 3/) toxicity for human cells in the diffusion chamber assay system have continued. Further investigation of this arsenic-induced cytotoxicity has demonstrated a linear dose-response relationship and a difference in the permanence of the growth inhibitory effect using different doses.

• Research Organization: Oak Ridge National Lab., TN (USA)
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 6773915
• Report Number(s): ORNL/TM-7411
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702 -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
560301 -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
560306 -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMAL CELLS
ANIMALS
ANTINEOPLASTIC DRUGS
ARSENIC COMPOUNDS
ARSENIC OXIDES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL LOCALIZATION
BODY
CARBON 11
CARBON ISOTOPES
CARBOXYLIC ACID ESTERS
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CELL PROLIFERATION
CHALCOGENIDES
CHEMICAL PREPARATION
COMPLEXES
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
ENDOCRINE GLANDS
ESTERS
EVEN-ODD NUCLEI
FEASIBILITY STUDIES
GLANDS
HEART
HEAVY NUCLEI
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MATERIALS
MINUTES LIVING RADIOISOTOPES
MUSCLES
MYOCARDIAL INFARCTION
MYOCARDIUM
NEOPLASMS
NUCLEI
ORGANIC ACIDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PANCREAS
PLATINUM 195
PLATINUM COMPLEXES
PLATINUM ISOTOPES
POSITRON COMPUTED TOMOGRAPHY
PRIMATES
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
RATS
RODENTS
SCINTISCANNING
SELENIUM 75
SELENIUM COMPOUNDS
SELENIUM ISOTOPES
STABLE ISOTOPES
SYNTHESIS
TELLURIUM 123
TELLURIUM COMPOUNDS
TELLURIUM ISOTOPES
TISSUE DISTRIBUTION
TOMOGRAPHY
TOXICITY
TRANSITION ELEMENT COMPLEXES
VERTEBRATES