Nuclear medicine technology progress report for quarter ending June 30, 1979

Technical Report · Wed Aug 01 04:00:00 EDT 1979

DOI:https://doi.org/10.2172/5975530· OSTI ID:5975530

Knapp, Jr., F. F.

Diffusion chamber assay system studies on the relative cytotoxicity and target cell uptake of /sup 195m/Pt-labeled cis- and trans-dichlorodiammineplatinum(II) (cis- and trans-DDP) are reported. These two agents are excellent candidates for such studies since cis-DDP is an established potent antitumor agent while the trans-isomer exhibits little antitumor activity. The KB tumor cell population in chambers from the cis-DDP-treated animals decreased while the cell population in chambers from the trans-DDP-treated animals increased. Cytotoxicity data obtained in the study are similar to results from in vivo studies. The results of continuing studies with /sup 117m/Sn, /sup 123m/Te, /sup 75/Se, /sup 11/C, and /sup 195m/Pt-labeled agents are also described. A series of five /sup 117m/Sn-labeled steroids containing a variety of structural modifications have been prepared. Future tissue distribution studies in rats will determine the potential usefulness of these agents for adrenal imaging applications. Based upon our studies with /sup 75/Se-labeled steroids (adrenal imaging) and fatty acids (myocardial imaging), the potential use of the /sup 73/Se-labeled agents for emission computerized axial tomographic applications is also discussed. Calculations of the estimated radiation dose to humans from two /sup 123m/Te-labeled steroids which suggest the potential clinical usefulness of these agents for adrenal visualization have been completed. Patient studies have continued with /sup 11/C-aminocyclobutanecarboxylic acid (ACBC) and /sup 11/C-tryptophan. Continuing studies with /sup 195m/Pt-labeled antitumor agents are also reported. (ERB)

• Research Organization: Oak Ridge National Lab., TN (USA)
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 5975530
• Report Number(s): ORNL/TM-6958
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702 -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
560171 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Man-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL GLANDS
AMINO ACIDS
ANIMAL CELLS
ANIMALS
ANTINEOPLASTIC DRUGS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BODY
CARBON 11
CARBON ISOTOPES
CARBOXYLIC ACID ESTERS
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CAT SCANNING
CHEMICAL PREPARATION
CLOUD CHAMBERS
COMPLEXES
COUNTING TECHNIQUES
DATA
DATA FORMS
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIFFUSION CHAMBERS
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
DOSES
DRUGS
ECAT SCANNING
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
ESTERS
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
GAS TRACK DETECTORS
GLANDS
GROWTH
HEART
HEAVY NUCLEI
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
IN VIVO
INDOLES
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOLATED VALUES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOMERS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MEASURING INSTRUMENTS
MINUTES LIVING RADIOISOTOPES
MUSCLES
MYOCARDIUM
NEOPLASMS
NUCLEI
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PANCREAS
PATIENTS
PHOTON EMISSION SCANNING
PHOTON TRANSMISSION SCANNING
PLATINUM 195
PLATINUM COMPLEXES
PLATINUM ISOTOPES
PYRROLES
RADIATION DETECTORS
RADIATION DOSES
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
RATS
RODENTS
SCINTISCANNING
SELENIUM 75
SELENIUM ISOTOPES
STABLE ISOTOPES
STEROIDS
SYNTHESIS
TELLURIUM 123
TELLURIUM ISOTOPES
TIN 117
TIN ISOTOPES
TISSUE DISTRIBUTION
TOMOGRAPHY
TOXICITY
TRANSITION ELEMENT COMPLEXES
TRYPTOPHAN
TUMOR CELLS
VERTEBRATES