Nuclear Medicine Technology. Progress report for quarter ending September 30, 1978

Technical Report · Thu Feb 01 04:00:00 EST 1979

DOI:https://doi.org/10.2172/6459559· OSTI ID:6459559

A unique class of radiopharmaceuticals labeled with the /sup 117m/Sn nuclide has been developed. The attractive properties of /sup 117m/Sn include a 14-day physical half-life and the emission of a single ..gamma..-photon with an optimal energy of 159 keV. A specialized apparatus was designed for the conversion of metallic /sup 117m/Sn to /sup 117m/SnCl/sub 4/ which was subsequently converted to a variety of useful /sup 117m/Sn-labeled organotin intermediates. The availability of this unique approach will now make possible the synthesis of a wide variety of /sup 117m/Sn-labeled compounds of biological interest. Such tissue-specific /sup 117m/Sn-labeled agents may represent a new class of useful radiopharmaceuticals. Continuing studies involving the preparation and testing of radiopharmaceuticals labeled with /sup 11/C, /sup 195m/Pt, and /sup 75/Se are also described. Several /sup 11/C-labeled amino acids including /sup 11/C-DL-tryptophan, /sup 11/C-1-aminocyclobutanecarboxylic acid (ACBC), and /sup 11/C-1-aminocyclopentanecarboxylic acid (ACPC) were prepared, and patient studies have demonstrated ACBC to be superior to ACPC for tumor localization. Studies with /sup 195m/Pt have recently been directed toward attempting to prepare high specific activity /sup 195m/Pt by the Szilard--Chalmers process. Progress is also reported in the development of an in vivo diffusion chamber assay technique that is being used to investigate the cytotoxicity of cyclophosphamide and cis-dichlorodiammineplatinum(II) on the growth of KB tumor cells. More recent studies with /sup 75/Se-labeled ..beta..-aminoethyl selenosulfate have demonstrated the significant pancreatic uptake of this agent. (ERB)

• Research Organization: Oak Ridge National Lab., TN (USA)
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 6459559
• Report Number(s): ORNL/TM-6639
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702* -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
AMINO ACIDS
ANIMAL CELLS
ANIMALS
ANTIMITOTIC DRUGS
AZOLES
BARYON REACTIONS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOASSAY
BIOLOGICAL LOCALIZATION
BODY
CARBON 11
CARBON ISOTOPES
CARBOXYLIC ACID ESTERS
CARBOXYLIC ACIDS
CHEMICAL PREPARATION
CHEMISTRY
DATA
DATA FORMS
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
ENDOXAN
ESTERS
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
GLANDS
GROWTH
HADRON REACTIONS
HEAVY NUCLEI
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
IN VIVO
INDOLES
INFORMATION
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
INTRAVENOUS INJECTION
ISOLATED VALUES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE PRODUCTION
ISOTOPES
LABELLED COMPOUNDS
LABELLING
LIGHT NUCLEI
MAMMALS
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NEUTRON REACTIONS
NUCLEAR REACTIONS
NUCLEI
NUCLEON REACTIONS
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PANCREAS
PLATINUM 195
PLATINUM COMPOUNDS
PLATINUM ISOTOPES
PYRROLES
RADIOACTIVE MATERIALS
RADIOCHEMISTRY
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
RATS
RODENTS
SELENIUM 75
SELENIUM COMPOUNDS
SELENIUM ISOTOPES
STABLE ISOTOPES
STEROIDS
SULFUR COMPOUNDS
SYNTHESIS
TIN 117
TIN ISOTOPES
TISSUE DISTRIBUTION
TOXICITY
TRANSITION ELEMENT COMPOUNDS
TRYPTOPHAN
TUMOR CELLS
VERTEBRATES