Nuclear medicine technology. Progress report for quarter ending December 31, 1978

Technical Report · Tue May 01 04:00:00 EDT 1979

DOI:https://doi.org/10.2172/5639755· OSTI ID:5639755

Knapp, Jr., F. F.

Of special interest is the recent synthesis of /sup 117m/Sn-labeled 12,12-dimethyl-12-stannahexadecanoic acid. Although tissue distribution studies with this potential myocardial imaging agent demonstrated only marginal heart uptake of radioactivity, these studies are important since they clearly demonstrate that tissue-specific /sup 117m/Sn-labeled agents can be prepared. High-quality heart scans in rats that have been obtained following intravenous administration of /sup 123m/Te-labeled 9-tellurahepta-decanoic acid are also illustrated. Continuing studies with /sup 11/C and /sup 195m/Pt are described. Additional patient studies with /sup 11/C-DL-tryptophan and /sup 11/C-1-aminocyclobutanecarboxylic acid (/sup 11/C-ACBC) have further illustrated the usefulness of these agents for the positron emission tomographic imaging studies of the pancreas and tumor tissue, respectively. Studies of the reactor production of /sup 195m/Pt by the Szilard-Chalmers process have been completed. These studies have demonstrated that the preparation of high specific activity /sup 195m/Pt by the Szilard-Chalmers process using this technique is impractical. Finally, continued studies with the KB tumor cell diffusion chamber technique have shown that a dose-response relationship can be demonstrated following injection of both cyclophosphamide and cis-dichlorodiammineplatinum (II). These results suggest that the diffusion chamber technique could be an important tool to study the uptake and effects on cell growth of radiopharmaceuticals and other agents.

• Research Organization: Oak Ridge National Lab., TN (USA)
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 5639755
• Report Number(s): ORNL/TM-6771
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702 -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
440101 -- Radiation Instrumentation-- General Detectors or Monitors & Radiometric Instruments
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY
550600 -- Medicine
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
AMINO ACIDS
ANIMAL CELLS
ANIMALS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BODY
CARBON 11
CARBON ISOTOPES
CARBOXYLIC ACID ESTERS
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CAT SCANNING
CHEMICAL PREPARATION
CHEMISTRY
CHEMOTHERAPY
CLOUD CHAMBERS
COMPLEXES
COMPUTERS
COUNTING TECHNIQUES
DATA PROCESSING
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ECAT SCANNING
ENDOCRINE GLANDS
ENDOXAN
ESTERS
EVEN-ODD NUCLEI
GAS TRACK DETECTORS
GLANDS
HEART
HEAVY NUCLEI
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HOT ATOM CHEMISTRY
INDOLES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MEASURING INSTRUMENTS
MINUTES LIVING RADIOISOTOPES
MUSCLES
MYOCARDIUM
NEOPLASMS
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PANCREAS
PERFORMANCE TESTING
PHOTON EMISSION SCANNING
PHOTON TRANSMISSION SCANNING
PLATINUM 195
PLATINUM COMPLEXES
PLATINUM ISOTOPES
PROCESSING
PYRROLES
RADIATION DETECTORS
RADIOACTIVE MATERIALS
RADIOCHEMISTRY
RADIOISOTOPE SCANNERS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
RODENTS
STABLE ISOTOPES
SYNTHESIS
TELLURIUM 123
TELLURIUM ISOTOPES
TESTING
THERAPY
TIN 117
TIN ISOTOPES
TISSUE DISTRIBUTION
TOMOGRAPHY
TOXICITY
TRANSITION ELEMENT COMPLEXES
TRYPTOPHAN
TUMOR CELLS
VERTEBRATES