Production of interferon-gamma by in vivo tumor-sensitized T cells: Association with active antitumor immunity
- Bristol-Myers Company, Wallingford, CT (USA)
The state of active immunity to Meth A fibrosarcoma in mice immunized with an admixture of Meth A cells and Propionibacterium acnes is associated with possession by the host of spleen cells capable of producing interferon-gamma (IFN-gamma) upon in vitro restimulation with irradiated tumor cells. The ability of spleen cells from immunized mice to produce IFN-gamma in response to irradiated Meth A cells decays as active antitumor immunity is replaced by a state of immunological memory. The IFN-producing cells are L3T4+Ly2+, cyclophosphamide-sensitive and radiosensitive T cells, as determined by their sensitivity to corresponding monoclonal antibodies and complement. The induction of IFN-gamma production by in vivo tumor-sensitized T cells is tumor specific, in that spleen cells from mice immunized against Meth A fibrosarcoma can produce IFN in response to irradiated Meth A cells but not in response to another syngeneic tumor M109 lung carcinoma.
- OSTI ID:
- 7044644
- Journal Information:
- Journal of Interferon Research; (USA), Journal Name: Journal of Interferon Research; (USA) Vol. 10:1; ISSN 0197-8357; ISSN JIRED
- Country of Publication:
- United States
- Language:
- English
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