Enhanced antitumor reactivity of tumor-sensitized T cells by interferon alfa

Journal Article · Fri Mar 01 04:00:00 EST 1991 · Archives of Surgery (Chicago); (USA)

DOI:https://doi.org/10.1001/archsurg.1991.01410270047009· OSTI ID:5836678

Vander Woude, D L; Wagner, P D; Shu, S; Chang, A E ^[1]

---

1. Univ. of Michigan, Ann Arbor (USA)

Tumor-draining lymph node cells from mice bearing the methylcholanthrene-induced MCA 106 tumors can be sensitized in vitro to acquire antitumor reactivity. We examined the effect of interferon alfa on the function of cells that underwent in vitro sensitization in adoptive immunotherapy. Interferon alfa increased the antitumor reactivity of in vitro sensitized cells in the treatment of MCA 106 pulmonary metastases. This effect was evident in irradiated mice, indicating that a host response to the interferon alfa was not required. Interferon alfa treatment increased class I major histocompatibility complex antigen expression on tumor cells and increased their susceptibility to lysis by in vitro sensitized cells. These results suggest that interferon alfa enhancement of adoptive immunotherapy was mediated by its effect on tumor cells. Interferon alfa may be a useful adjunct to the adoptive immunotherapy of human cancer.

• OSTI ID: 5836678
• Journal Information: Archives of Surgery (Chicago); (USA), Journal Name: Archives of Surgery (Chicago); (USA) Vol. 126:3; ISSN ARSUA; ISSN 0004-0010
• Country of Publication: United States
• Language: English

Related Subjects

3-METHYLCHOLANTHRENE
560152 -- Radiation Effects on Animals-- Animals
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AROMATICS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARCINOGENESIS
CONNECTIVE TISSUE CELLS
EXPERIMENTAL NEOPLASMS
EXTERNAL IRRADIATION
GROWTH FACTORS
HYDROCARBONS
INTERFERON
IRRADIATION
LEUKOCYTES
LUNGS
LYMPH NODES
LYMPHATIC SYSTEM
LYMPHOCYTES
LYMPHOKINES
LYSIS
MAMMALS
MATERIALS
MICE
MITOGENS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
POLYCYCLIC AROMATIC HYDROCARBONS
PROTEINS
RESPIRATORY SYSTEM
RODENTS
SOMATIC CELLS
TUMOR CELLS
VERTEBRATES
WHOLE-BODY IRRADIATION