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Mutation induction by very low dose rate gamma rays in cultured mouse leukemia cells L5178Y

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3577163· OSTI ID:7037541
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Induction of cell killing and mutation to 6-thioguanine resistance was studied in growing mouse leukemia cells in culture following gamma rays at dose rates of 30 Gy/h, 20 cGy/h, and 6.3 mGy/h, i.e., acute, low dose rate, and very low dose rate irradiation. A marked increase was observed in the cell survival with decreasing dose rate; no reduction in the surviving fraction was detected after irradiation at 6.3 mGy/h until a total dose of 4 Gy. Similarly, the induced mutation frequency decreased after low dose rate irradiation compared to acute irradiation. However, the frequency after irradiation at 6.3 mGy/h was unexpectedly high and remained at a level which was intermediate between acute and low dose rate irradiation. No appreciable changes were observed in the responses to acute gamma rays (in terms of cell killing and mutation induction) in the cells which had experienced very low dose rate irradiation.

Research Organization:
National Institute of Radiological Sciences, Chiba-shi (Japan)
OSTI ID:
7037541
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 115:2; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL CULTURES
CELL KILLING
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELECTROMAGNETIC RADIATION
FRACTIONATED IRRADIATION
GAMMA RADIATION
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
HEMIC DISEASES
IMMUNE SYSTEM DISEASES
IONIZING RADIATIONS
IRRADIATION
LEUKEMIA
LOW DOSE IRRADIATION
MAMMALS
MICE
MUTATION FREQUENCY
MUTATIONS
NEOPLASMS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RODENTS
SURVIVAL TIME
TUMOR CELLS
VERTEBRATES