Mutation induction by different dose rates of gamma rays in radiation-sensitive mutants of mouse leukemia cells

Journal Article · Wed Nov 01 04:00:00 EST 1989 · Radiation Research; (USA)

DOI:https://doi.org/10.2307/3577722· OSTI ID:6992788

Furuno-Fukushi, I; Matsudaira, H ^[1]

---

1. National Institute of Radiological Sciences, Chiba-shi (Japan)

Induction of cell killing and mutation to 6-thioguanine resistance was examined in a radiation-sensitive mutant strain LX830 of mouse leukemia cells following gamma irradiation at dose rates of 30 Gy/h (acute), 20 cGy/h (low dose rate), and 6.2 mGy/h (very low dose rate). LX830 cells were hypersensitive to killing by acute gamma rays. A slight but significant increase was observed in cell survival with decreasing dose rate down to 6.2 mGy/h, where the survival leveled off above certain total doses. The cells were also hypersensitive to mutation induction compared to the wild type. The mutation frequency increased linearly with increasing dose for all dose rates. No significant difference was observed in the frequency of induced mutations versus total dose at the three different dose rates so that the mutation frequency in LX830 cells at 6.2 mGy/h was not significantly different from that for moderate or acute irradiation.

• OSTI ID: 6992788
• Journal Information: Radiation Research; (USA), Journal Name: Radiation Research; (USA) Vol. 120:2; ISSN 0033-7587; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
CELL KILLING
COBALT ISOTOPES
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
HEMIC DISEASES
IMMUNE SYSTEM DISEASES
IN VITRO
IONIZING RADIATIONS
ISOTOPES
LEUKEMIA
MAMMALS
MICE
MUTATION FREQUENCY
MUTATIONS
NEOPLASMS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY
RODENTS
SURVIVAL TIME
TUMOR CELLS
VERTEBRATES