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Mutation induction by tritiated water and effects of deuterium oxide in cultured mouse leukemia cells

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3576770· OSTI ID:5198472
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Induction of mutation to 6-thioguanine resistance was studied in L5178Y mouse leukemia cells after exposure to low-dose-rate ..gamma.. rays or tritiated water at dose rates of approximately 0.025 to 0.4 Gy/hr for 20 hr in the presence or absence of 45% (v/v) deuterium oxide. The effect of acute-..gamma.. ray exposure was also examined. A higher frequency of induced mutations was observed after tritium ..beta.. rays than after ..gamma.. rays, both at equivalent doses and cell survival. Deuterium oxide enhanced the mutation induced by ..gamma.. rays and tritium ..beta.. rays but did not affect the survival-mutation correlation of the two radiations.

Research Organization:
National Institute of Radiological Sciences, Chiba-shi, Japan
OSTI ID:
5198472
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 103:3; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA PARTICLES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGY
CHALCOGENIDES
CHARGED PARTICLES
COBALT 60
COBALT ISOTOPES
DISEASES
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
HEAVY WATER
HEMIC DISEASES
HYDROGEN COMPOUNDS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LEUKEMIA
LOW DOSE IRRADIATION
MAMMALS
MICE
MINUTES LIVING RADIOISOTOPES
MUTATION FREQUENCY
MUTATIONS
NEOPLASMS
NUCLEI
ODD-ODD NUCLEI
OXIDES
OXYGEN COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOBIOLOGY
RADIOINDUCTION
RADIOISOTOPES
RODENTS
TRITIUM COMPOUNDS
TRITIUM OXIDES
TUMOR CELLS
VERTEBRATES
WATER
YEARS LIVING RADIOISOTOPES