Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

Induction of cell killing, micronuclei, and mutation to 6-thioguanine resistance after exposure to low-dose-rate. gamma. rays and tritiated water in cultured mammalian cells (L5178Y). [/sup 60/Co]

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3575884· OSTI ID:6942234

Cell killing and induction of micronuclei and mutation to 6-thioguanine resistance were studied in growing cultured mammalian cells (L5178Y) after exposure for a fixed period to low-dose-rate ..gamma.. rays and tritiated water (HTO) at comparable dose rates, from about 10 to 40 rad/hr. From the analysis of dose-response relationships, RBE values of HTO ..beta.. rays relative to ..gamma.. rays were calculated. These were 1.5 for cell killing, 2.0 for micronuclei, and 1.8 for mutation induction. Reported RBE values for HTO were reviewed.

Research Organization:
National Inst. of Radiological Sciences, Chiba-shi, Japan
OSTI ID:
6942234
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 91:3; ISSN RAREA
Country of Publication:
United States
Language:
English

Similar Records

Cell killing and mutation to 6-thioguanine resistance after exposure to tritiated amino acids and tritiated thymidine in cultured mammalian cells (L5178Y)
Journal Article · Mon Jun 01 00:00:00 EDT 1987 · Radiat. Res.; (United States) · OSTI ID:6465853

Mutation induction by tritiated water and effects of deuterium oxide in cultured mouse leukemia cells
Journal Article · Sun Sep 01 00:00:00 EDT 1985 · Radiat. Res.; (United States) · OSTI ID:5198472

Cell killing by gamma rays and beta particles from tritiated water and incorporated tritiated thymidine
Journal Article · Mon Sep 01 00:00:00 EDT 1975 · Radiat. Res., v. 63, no. 3, pp. 531-543 · OSTI ID:4162976