Studies on the biodisposition of organophosphates in mice. Annual summary report, 1 August 1982-31 July 1983

Technical Report · Mon Aug 01 04:00:00 EDT 1983

OSTI ID:7037160

Martin, B R

The biodisposition of radioactivity was studied in mice following the i.v. administration of 3H-DFP (1 mg/kg). EH-DFP penetrated tissues rapidly so that within 1 min of drug administration, maximal levels of radioactivity were found in brain, lung, heart and kidney. The peak levels of radioactivity in liver, diaphragm and fat occurred at 5 min. Tissue levels remained elevated for approximately 8 hr. The rank order of tissue concentrations during this period of time was liver > plasma > kidney > heart = diaphragm > = fat. Radioactivity declined appreciably by 3 days, and after 7 days the highest concentrations were found in liver and lung with somewhat lower concentrations in kidney. It may be that lung and liver are potential storage depots under certain circumstances. Radioactivity was readily extracted from brain homogenates (85% removed by ethyl acetate) 1 min after administration, but the amount that was nonextractable increased with time. A relatively small portion (13-24%) of the radioactivity was extractable from the other tissues at the early time points, but even these small percentages decreased with time. It appears that enzyme aging occurs slowly or to a limited degree in mice, but further experimentation will be necessary to establish the extent to which it occurs.

• Research Organization: Medical Coll. of Virginia, Richmond, VA (United States). Dept. of Pharmacology and Toxicology
• OSTI ID: 7037160
• Report Number(s): AD-B-090890/5/XAB; CNN: DAMD17-82-C-2212
• Country of Publication: United States
• Language: English

Related Subjects

45 MILITARY TECHNOLOGY, WEAPONRY, AND NATIONAL DEFENSE
450600* -- Military Technology
Weaponry
& National Defense-- Chemical & Biological-- (1990)
BIOLOGICAL ACCUMULATION
CHEMICAL WARFARE AGENTS
DOCUMENT TYPES
MEDICINE
PREVENTIVE MEDICINE
PROGRESS REPORT
TOXICITY
WEAPONS