Disposition of phencyclidine in mice after smoke exposure

Journal Article · · Drug Metab. Dispos.; (United States)

OSTI ID:6217529

Freeman, A S; Martin, B R

Mice were exposed to the smoke from placebo marihuana cigarettes treated with phencyclidine hydrochloride (PCP . HCl). A dose-related decrement in motor performance was observed after exposure to the smoke from cigarettes containing 10-15 mg of PCP . HCl. Tissue levels of /sup 3/H-PCP, /sup 3/H-PC (pyrolysis product), and /sup 3/H-metabolites were measured in several tissues up to 7 days after exposure to 50 mg of /sup 3/H-PCP . HCl. /sup 3/H-PCP levels were highest in liver followed by lung, brain, fat, and plasma for the first 10 min after exposure. The /sup 3/H-PCP concentration in all tissues, except fat, declined during the subsequent 50 min. Liver and lung contained the highest levels of /sup 3/H-metabolites during this hour, followed by plasma, fat, and brain. Brain levels of /sup 3/H-PCP correlated well with the magnitude and duration of behavioral effects observed (r . 0.98). /sup 3/H-PC was also well absorbed from smoke as evidenced by initial tissue levels comparable to those of /sup 3/H-PCP, but they declined more rapidly than /sup 3/H-PCP levels. Excellent correlations were obtained between /sup 3/H-PCP and /sup 3/H-PC concentrations in plasma and those in liver, lung, and brain. /sup 3/H-PCP was not detected in any tissue 3 days after smoke exposure. At 1 and 3 days, radioactivity corresponding to metabolites persisted in liver and lung, but had largely disappeared by 7 days.

• Research Organization: Department of Pharmacology, Medical College of Virginia, Virginia Commonwealth University, Richmond
• OSTI ID: 6217529
• Journal Information: Drug Metab. Dispos.; (United States), Journal Name: Drug Metab. Dispos.; (United States) Vol. 10:6; ISSN DMDSA
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANESTHETICS
ANIMALS
BEHAVIOR
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM DEPRESSANTS
COLLOIDS
DIGESTIVE SYSTEM
DISPERSIONS
DISTRIBUTION
DRUGS
GLANDS
HERBS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LIVER
LUNGS
MAMMALS
MARIHUANA
METABOLISM
METABOLITES
MICE
NERVOUS SYSTEM
ORGANS
PLANTS
RESIDUES
RESPIRATORY SYSTEM
RODENTS
SMOKES
SOLS
SYNERGISM
TISSUE DISTRIBUTION
TOBACCO SMOKES
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES