Biodisposition of organophosphates in mice and rats. Annual summary report No. 1, 1 August 1982-31 July 1983

Technical Report · Mon Aug 01 04:00:00 EDT 1983

OSTI ID:5176846

Martin, B R

The biodisposition of radioactivity was studied in mice following the i.v. administration /sup 3/H-DFP (1 mg/kg). /sup 3/H-DFP penetrated tissues rapidly so that within 1 min of drug administration, maximal levels of radioactivity were found in brain, lung, heart and kidney. The peak levels of radioactivity in liver, diaphragm and fat occured at 5 min. Tissue levels remained elevated for approximately 8 hr. The rank order of tissue concentrations during this period of time was liver > plasma > kidney > lung > heart = diaphragm > brain = fat. Radioactivity declined appreciably by 3 days, and after 7 days the highest concentrations were found in liver and lung with somewhat lower concentrations in kidney. It may be that lung and liver may be potential storage depots under certain circumstances. Radioactivity was readily extracted from brain homogenates (55% removed by ethyl acetate) 1 min after administration but the amount that was nonextractable increased with time. A relatively small portion (13-24%) of the radioactivity was extractable from the other tissues at the early time points but even these small precentages decreased with time. It appears that enzyme aging occurs slowly or to a limited degree in mice but further experimentation will be necessary to establish the extent to which it occurs.

• Research Organization: Medical Coll. of Virginia, Richmond (USA). Dept. of Pharmacology
• OSTI ID: 5176846
• Report Number(s): AD-A-135754/0
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADIPOSE TISSUE
ANIMAL TISSUES
ANIMALS
BIOASSAY
BIOLOGICAL MATERIALS
BLOOD
BLOOD PLASMA
BODY
BODY FLUIDS
BRAIN
CARBOXYLESTERASES
CENTRAL NERVOUS SYSTEM
CHOLINESTERASE
CONNECTIVE TISSUE
DIAPHRAGM
DISTRIBUTION
ENZYMES
ESTERASES
HYDROLASES
ISOTOPE APPLICATIONS
KIDNEYS
LABELLED COMPOUNDS
LUNGS
MAMMALS
MATERIALS
MICE
MUSCLES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
RATS
RESPIRATORY SYSTEM
RODENTS
TISSUE DISTRIBUTION
TISSUES
TOXICITY
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES