Discriminative stimulus properties and brain distribution of phencyclidine in rats following administration by injection and smoke inhalation

Journal Article · Tue Oct 01 04:00:00 EDT 1985 · Pharmacol., Biochem. Behav.; (United States)

DOI:https://doi.org/10.1016/0091-3057(85)90425-3· OSTI ID:5810280

Wessinger, W D; Martin, B R; Balster, R L

Four male Sprague-Dawley rats were trained to discriminate IP injections of 3.0 mg/kg phencyclidine (PCP) from saline under a 2-lever fixed-ratio 32 schedule of food presentation. After reliable discriminative control of lever choice was established, other doses of injected PCP were tested resulting in dose-dependent increases in PCP-lever selection and dose-dependent decreases in rates of responding. When doses of PCP were administered by exposure to smoke from cigarettes containing PCP, a dose-dependent increase in PCP-lever responding was also observed. delta 9-Tetrahydrocannabinol administered via smoke exposure, up to doses which markedly suppressed response rates, did not result in PCP-appropriate responding, demonstrating the specificity of the PCP stimulus by the inhalation route. Brain levels and distribution of /sup 3/H-PCP were determined in rats administered doses calculated to result in 50% generalization by the IP injection or smoke inhalation routes. By both routes of administration roughly equivalent brain levels were attained and the distribution was relatively even across the seven brain areas analyzed. These results demonstrate the validity of using the injection route of administration when studying PCP experimentally, in spite of the fact that PCP is abused primarily by smoking.

• OSTI ID: 5810280
• Journal Information: Pharmacol., Biochem. Behav.; (United States), Journal Name: Pharmacol., Biochem. Behav.; (United States) Vol. 4; ISSN PBBHA
• Country of Publication: United States
• Language: English

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550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AEROSOLS
AMINES
ANIMALS
AZINES
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
COLLOIDS
DISPERSIONS
DISTRIBUTION
DOSE-RESPONSE RELATIONSHIPS
HETEROCYCLIC COMPOUNDS
INHALATION
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
MAMMALS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PIPERIDINES
PYRIDINES
RATS
RESIDUES
RODENTS
SMOKES
SOLS
STIMULI
TISSUE DISTRIBUTION
TOBACCO SMOKES
VERTEBRATES