Identification and quantification of phencyclidine pyrolysis products formed during smoking

Journal Article · · J. Anal. Toxicol.; (United States)

DOI:https://doi.org/10.1093/jat/10.3.81· OSTI ID:6848746

Lue, L P; Scimeca, J A; Thomas, B F; Martin, B R

As a result of frequent phencyclidine (PCP) abuse, pyrolysis studies were conducted to further investigate its fate during smoking. Marijuana placebo cigarettes were impregnated with /sup 3/H-PCP HCl and burned under conditions simulating smoking. Mainstream smoke was passed through glass wool filters as well as acidic and basic traps. Approximately 90% of the starting material could be accounted for in the first glass wool trap and cigarette holder. HPLC and GC/MS analysis of methanol extracts of these glass wool traps revealed the presence of 1-phenyl-1-cyclohexene (47% of the starting material) > PCP (40%) > piperidine (15%) > N-acetylpiperidine (9%). It was not possible to fully account for the remainder of the piperidine moiety. It has been reported that at high temperatures PCP is converted to numerous polynuclear aromatic compounds which include styrene, ..cap alpha..-methylstyrene, naphthalene, 2-methyl-naphthalene, 1-methylnaphthalene, biphenyl, cyclohexylbenzene, acenaphthene, phenanthrene, and anthracene. These compounds were not formed from PCP under smoking conditions.

• Research Organization: Virginia Commonwealth Univ., Richmond
• OSTI ID: 6848746
• Journal Information: J. Anal. Toxicol.; (United States), Journal Name: J. Anal. Toxicol.; (United States) Vol. 10:3; ISSN JATOD
• Country of Publication: United States
• Language: English

Related Subjects

500101* -- Environment
Atmospheric-- Basic Studies-- Radiometric Techniques-- (-1989)
54 ENVIRONMENTAL SCIENCES
560300 -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AROMATICS
CENTRAL NERVOUS SYSTEM AGENTS
CHEMICAL ANALYSIS
CHEMICAL REACTIONS
COLLOIDS
DECOMPOSITION
DISPERSIONS
DRUGS
HYDROCARBONS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
ORGANIC COMPOUNDS
POLYCYCLIC AROMATIC HYDROCARBONS
PSYCHOTROPIC DRUGS
PYROLYSIS
QUALITATIVE CHEMICAL ANALYSIS
QUANTITATIVE CHEMICAL ANALYSIS
RESIDUES
SMOKES
SOLS
THERMOCHEMICAL PROCESSES
TRACER TECHNIQUES
TRITIUM COMPOUNDS