Effects of. gamma. irradiation on cartilage matrix calcification

Journal Article · Wed Oct 01 04:00:00 EDT 1980 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575218· OSTI ID:7029085

Nijweide, P J ^[1]; Burger, E H; van Delft, J L; Kawilarange-de Haas, E W.M.; Wassenaar, A M; Mellink, J H

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1. Leiden Univ., Netherlands

The effect of ..gamma.. irradiation on cartilage matrix calcification was studied in vitro. Metatarsal bones of 14- to 17-day-old embryonic mice were dissected and cultured under various conditions. Prior to culture, half of the metatarsal bones received absorbed doses of 1.0 to 30.0 Gy ..gamma.. radiation. Their paired counterparts served as controls. Irradiation inhibited longitudinal growth and calcification of the cartilage matrix during culture. In addition, a number of histological changes were noted. The inhibition of matrix calcification appeared to be due to an inhibition of the intracellular calcium accumulation. The formation of extracellular calcification foci and the growth of the calcified area already present at the moment of explanation were not inhibited during culture.

• OSTI ID: 7029085
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 84:1; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

550500 -- Metabolism
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH METALS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CALCIUM
CARTILAGE
CONNECTIVE TISSUE
DATA
DOSES
ELECTROMAGNETIC RADIATION
ELEMENTS
EMBRYOS
EXPERIMENTAL DATA
GAMMA RADIATION
GROWTH
HISTOLOGY
IN VITRO
INFORMATION
INHIBITION
IONIZING RADIATIONS
MAMMALS
METABOLISM
METALS
MICE
NUMERICAL DATA
ONTOGENESIS
ORGANS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RODENTS
SKELETON
TISSUE CULTURES
TISSUES
VERTEBRATES