Salicylic acid failed to increase the efficacy of Ca-DTPA in the decorporation of plutonium and americium
Male and female C57BL/Do mice were each given a single ip injection of /sup 237 + 239/Pu + /sup 241/Am as the citrate complex at 45 days of age. Twice-weekly ip injections of either 500 ..mu..mole/kg Ca-DTPA or 500 ..mu..mole/kg Ca-DTPA mixed just before injection with 2000 ..mu..mole/kg salicylic acid (SA) were begun 3 days after nuclide administration and continued for 5 weeks. Control mice were injected each time with isotonic saline. Nuclide retention was determined by in vivo ..gamma..-ray counting using a NaI(Tl) crystal spectrometer. At the end of treatment, total-body retention of Pu or Am in the mice given Ca-DTPA was significantly lower (P < 0.001) than that in the control animals. Mice treated with Ca-DTPA plus SA were statistically indistinguishable from mice treated with Ca-DTPA alone (P > 0.70 for /sup 237/Pu and P > 0.20 for /sup 241/Am).
- Research Organization:
- Univ. of Utah, Salt Lake City
- DOE Contract Number:
- AC02-76EV00119
- OSTI ID:
- 7028623
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 84:1; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Removal of Pu and Am from beagles and mice by 3,4,3-LICAM(C) or 3,4,3-LICAMS(S)
Effect of Zn-DTPA therapy on the maternal transfer of /sup 241/Am or /sup 237/Pu to young mice
Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALKALINE EARTH METAL COMPOUNDS
ALPHA DECAY RADIOISOTOPES
AMERICIUM 241
AMERICIUM ISOTOPES
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
CALCIUM COMPOUNDS
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
COUNTING TECHNIQUES
DATA
DAYS LIVING RADIOISOTOPES
DETECTION
DRUGS
DTPA
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
EXCRETION
EXPERIMENTAL DATA
GAMMA DETECTION
HEAVY NUCLEI
HYDROXY ACIDS
INFORMATION
INJECTION
INTAKE
INTERNAL CONVERSION RADIOISOTOPES
INTRAPERITONEAL INJECTION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MICE
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
PLUTONIUM 237
PLUTONIUM 239
PLUTONIUM ISOTOPES
RADIATION DETECTION
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPROTECTIVE SUBSTANCES
RESPONSE MODIFYING FACTORS
RETENTION
RODENTS
SALICYLIC ACID
SECONDS LIVING RADIOISOTOPES
SYNERGISM
TIME DEPENDENCE
VERTEBRATES
WHOLE-BODY COUNTING
YEARS LIVING RADIOISOTOPES