Effect of Zn-DTPA therapy on the maternal transfer of /sup 241/Am or /sup 237/Pu to young mice
Newborn mice exposed to /sup 241/Am or /sup 237/Pu during gestation and whose mothers were given Zn-DTPA at various times before parturition contained less radioactivity than comparable newborn mice given identical /sup 241/Am or /sup 237/Pu exposure without Zn-DTPA treatment of the mothers. There was no net increase in radionuclide transfer from mothers to unborn young as a result of maternal administration of Zn-DTPA, regardless of the pregnancy stage during which the radioactivity and decorporation treatments were given. Administration of /sup 241/Am followed after three days by extended Zn-DTPA therapy resulted in lower fetal content of radioactivity in litters conceived long after or soon after maternal exposure to /sup 241/Am. These data indicate that the risk from Am and Pu to unborn young can be reduced by Zn-DTPA treatment of the pregnant mother and of the female who becomes pregnant subsequently. This information may prove to be of significance with the increasing probability of Am or Pu exposure to women in the nuclear industry who could be pregnant at the time or who may conceive a child in the future.
- Research Organization:
- Univ. of Utah, Salt Lake City
- DOE Contract Number:
- AC02-76EV00119
- OSTI ID:
- 5227613
- Journal Information:
- Health Phys.; (United States), Journal Name: Health Phys.; (United States) Vol. 49:3; ISSN HLTPA
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
AMERICIUM 241
AMERICIUM ISOTOPES
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
CARBOXYLIC ACID SALTS
CARBOXYLIC ACIDS
CHELATING AGENTS
CITRATES
CLEANING
COMPLEXES
DAYS LIVING RADIOISOTOPES
DECONTAMINATION
DRUGS
DTPA
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HEAVY NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MICE
NEONATES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
PLUTONIUM 237
PLUTONIUM ISOTOPES
PRENATAL EXPOSURE
RADIATION PROTECTION
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPROTECTIVE SUBSTANCES
RETENTION
RODENTS
SECONDS LIVING RADIOISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
ZINC COMPLEXES