Effect of age on the efficacy of Zn-diethylenetriaminepentaacetic acid therapy for removal of Am and Pu from beagles

Journal Article · Fri Mar 01 04:00:00 EST 1985 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576504· OSTI ID:5706951

Lloyd, R D; Mays, C W; Jones, C W; Lloyd, C R; Taylor, G N; Wrenn, M E

Decorporation of intravenously injected monomeric /sup 241/Am and /sup 237+239/Pu by the administration of 30 ..mu..mole Zn-diethylenetriaminepentaacetic acid (DTPA)/kg each day beginning 2 weeks after radionuclide injection was compared in beagles entered into the experiment when 3 months (juveniles), 1.9 years (young adults), or 10 years (mature adults) old and studied for about 5 months. DTPA therapy was most effective in the juvenile dogs and least effective in the mature adults. Retention of /sup 241/Am in the liver decreased from a pretreatment value for adults of about 50% of the injected activity to about 10% in the mature adults and less than 1% in the young adults at 140 days of treatment, while the liver retention of juveniles decreased from pretreatment values of about 16% to undetectable levels by 28 days of treatment. Plutonium retention in the liver decreased from adult pretreatment levels of about 30% to near 10% in the mature adults and 6% in the young adults at 140 days of treatment, while juvenile liver retention decreased from pretreatment values near 15% to undetectable levels by 56 days of treatment. Nonliver Am retention (mainly skeleton) decreased in mature adults from pretreatment values of about 45% of the injected activity to near 25%, in young adults from 35 to 20%, and in juveniles from roughly 70 to 9% by 140 days of DTPA administration. Nonliver Pu retention decreased from pretreatment values of about 50% for mature and young adults to about 30% by 140 days and from 75 to 16% in juveniles over the same period.

• Research Organization: Univ. of Utah, Salt Lake City
• DOE Contract Number: AC02-76EV00119
• OSTI ID: 5706951
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 101:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ADULTS
AGE DEPENDENCE
AGE GROUPS
ALPHA DECAY RADIOISOTOPES
AMERICIUM 241
AMERICIUM ISOTOPES
AMINO ACIDS
ANIMALS
BEAGLES
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DOGS
DRUGS
DTPA
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GLANDS
HEAVY NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
JUVENILES
LIVER
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PLUTONIUM 237
PLUTONIUM 239
PLUTONIUM ISOTOPES
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RETENTION
SECONDS LIVING RADIOISOTOPES
SKELETON
VERTEBRATES
YEARS LIVING RADIOISOTOPES
ZINC COMPOUNDS