Dependency of chelation efficacy upon time after first DTPA injection. [Beagles, /sup 241/Am, /sup 237/Pu, and /sup 23/Pu retention]
Fourteen young adult beagles were given an intravenous injection of either /sup 241/Am(III) citrate or /sup 239/Pu(IV) citrate (labeled with /sup 237/Pu) followed by a single intravenous injection of Ca-DTPA after an interval of 1 min, 6 min, 30 min, 150 min, 8 hr, 1 day, or 3 days. Animals were sacrificed 7 days after DTPA injection. Retention of /sup 241/Am at death was influenced strongly by early treatment. Dogs given Ca-DTPA at 1, 6, and 30 min retained about 3, 10, and 29% respectively, of the injected /sup 241/Am, while the animal treated at 150 min retained 45%. Beagles given /sup 241/Am and then DTPA at 8 hr, 1 day, and 3 days, retained 58, 73, and 72%, respectively. For /sup 241/Am contamination, the first DTPA treatment should be given as soon as possible. Total-body retention of /sup 239/ /sup +/ /sup 237/Pu was affected less dramatically be early treatment. The dogs given DTPA at 1, 6, and 30 min retained 31, 28, and 34% at death, while the Pu retention in the animal treated at 150 min was 44%, a value similar to that in the dog given /sup 241/Am and treated also at 150 min. At the later treatment times, the retention of Pu and Am seemed to be generally the same. Dogs given Pu and then DTPA at 8 hr, 1 day, and 3 days retained52, 5(, and 7(%, respectively. Even though delays of up to 30 min seemed to have little effect upon total-body retnetion after /sup 239/Pu exposure, early treatment at 1 and 6 min had a disproportionately greater effect in reducing th Pu in trabecular bone, where most osteosarcomas arise, as compared with cortical bone. Therefore, in the event of /sup 239/Pu intake by humans, treatment should begin as soon as possible. Earlier work indicates that frequent injections of Zn-DTPA should follow the initial Ca-DTPA treatment.
- Research Organization:
- Univ. of Utah, Salt Lake City
- OSTI ID:
- 5992867
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 78:3; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
AMERICIUM 241
AMERICIUM ISOTOPES
AMINO ACIDS
ANIMALS
BEAGLES
BETA DECAY RADIOISOTOPES
CARBOXYLIC ACID SALTS
CARBOXYLIC ACIDS
CHELATING AGENTS
CITRATES
CLEARANCE
DATA
DATA FORMS
DAYS LIVING RADIOISOTOPES
DOGS
DRUGS
DTPA
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
EXCRETION
EXPERIMENTAL DATA
HEAVY NUCLEI
INFORMATION
INJECTION
INTAKE
INTERNAL CONVERSION RADIOISOTOPES
INTRAVENOUS INJECTION
ISOLATED VALUES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
PLUTONIUM 237
PLUTONIUM 239
PLUTONIUM ISOTOPES
POST-IRRADIATION THERAPY
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPROTECTIVE SUBSTANCES
RESPONSE MODIFYING FACTORS
SECONDS LIVING RADIOISOTOPES
THERAPY
TIME DEPENDENCE
VERTEBRATES
YEARS LIVING RADIOISOTOPES