Pu and Am decorporation in beagles: effects of magnitude of initial Ca-DTPA injection upon chelation efficacy
To investigate the effects of magnitude of initial DTPA injection upon chelation efficacy, five young adult beagles were each given an intravenous injection of /sup 237 +239/Pu(IV) citrate + /sup 241/Am(III) citrate, followed by a single intravenous injection of Ca-DTPA 0.5 hr later. Amounts of this chelating agent administered were 3, 10, 30, 100, and 300 ..mu..mole Ca-DTPA/kg body mass. Animals were sacrificed 7 days later. Total-body retention of both plutonium and americium was influenced strongly by the amount of DTPA administered, although the removal of Pu by DTPA was less pronounced than that of Am; and in the range of 30 ..mu..mole/kg, an increase of DTPA administration by a factor of 2 resulted in only a 25% decrease in residual body content. Plutonium retention at 7 days was reduced from about 77% in the dog given 3 ..mu..mole/kg to 14% in the animal injected with 300 ..mu..mole/kg. Corresponding values for americium were 40 and 9%. Also, liver content of both Pu and Am was reduced significantly by larger amounts of administered DTPA, decreasing from 18 to 2% for Pu with increasing levels of DTPA, and from 21 to 1% for Am. If there is a level of Ca-DTPA administration at 30 min after injection in a beagle at which no additional chelation of Pu or Am is produced with increasing dosage, it is greater than 300 ..mu..mole/kg. In a 70-kg human, this would be equivalent to the injection of 10 g Ca-DTPA.
- Research Organization:
- Univ. of Utah Medical Center, Salt Lake City
- DOE Contract Number:
- EY-76-C-02-0119
- OSTI ID:
- 5756827
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 79:3; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALKALINE EARTH METALS
ALPHA DECAY RADIOISOTOPES
AMERICIUM 241
AMERICIUM ISOTOPES
AMINO ACIDS
ANIMALS
BEAGLES
BETA DECAY RADIOISOTOPES
CALCIUM
CARBOXYLIC ACIDS
CHELATING AGENTS
DAYS LIVING RADIOISOTOPES
DOGS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
DTPA
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
HEAVY NUCLEI
INJECTION
INTAKE
INTERNAL CONVERSION RADIOISOTOPES
INTRAVENOUS INJECTION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
METALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
PLUTONIUM 237
PLUTONIUM 239
PLUTONIUM ISOTOPES
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RESPONSE MODIFYING FACTORS
RETENTION
SECONDS LIVING RADIOISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES