Removal of Pu and Am from beagles and mice by 3,4,3-LICAM(C) or 3,4,3-LICAMS(S)

Journal Article · Sun Jul 01 04:00:00 EDT 1984 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576450· OSTI ID:6578195

Lloyd, R D; Bruenger, F W; Mays, C W; Atherton, D R; Jones, C W; Taylor, G N; Stevens, W; Durbin, P W; Jeung, N; Jones, E S

Decorporation of Pu and Am by tetrameric catecholylamide (CAM) ligands has been investigated in beagles and mice. Eight dogs were injected intravenously (iv) with /sup 237 +239/Pu(IV) + /sup 241/Am(III) citrate, and 30 min. later, pairs of dogs were injected iv with 3,4,3-LICAM(C), 3,4,3-LICAM(S), CaNa/sub 3/-DTPA, or each of the latter two ligands. Blood was sampled, and excreta were collected for 7 days, at which time the dogs were sacrificed and nuclide retention in liver and nonliver tissue was measured. Groups of five mice were each given /sup 238/Pu(IV) or /sup 241/Am(III) citrate iv; 3 min later a CAM ligand was injected intraperitoneally, mice were killed at 24 hr, and separated excreta and tissues were analyzed. In the dogs, average retention at 7 days of the injected Pu and Am, respectively, was as follows: 12 and 70% after treatment with a CAM ligand alone; 30 and 20% after DTPA; 12 and 20% after LICAM(S) plus DTPA; 90 and 89% without a ligand. In the mice, mean retention of the injected Pu and Am, respectively, was as follows: 14 and 66% after treatment with LICAM(C); 21 and 54% after LICAM(S); 91 and 87% without a ligand. LICAM(C) was more effective in removing Pu from liver and LICAM(S) was more effective in the skeleton. LICAM(C) is less acidic than LICAM(S), which reduces its ability to chelate Fe(III) at the pH of tubular urine, and its lesser hydrophilicity allows diversion of some ligand to the GI tract and away from the kidneys.

• Research Organization: Univ. of Utah, Salt Lake City
• DOE Contract Number: AC02-76EV00119
• OSTI ID: 6578195
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 99:1; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
AMERICIUM 241
AMERICIUM ISOTOPES
AMINES
AMINO ACIDS
ANIMALS
AROMATICS
BEAGLES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BLOOD PLASMA
BODY
BODY FLUIDS
CARBOXYLIC ACID SALTS
CARBOXYLIC ACIDS
CATECHOLAMINES
CHELATING AGENTS
CITRATES
CLEARANCE
DATA
DIGESTIVE SYSTEM
DISTRIBUTION
DOGS
DRUGS
DTPA
EVEN-EVEN NUCLEI
EXCRETION
EXPERIMENTAL DATA
FECES
GLANDS
HEAVY NUCLEI
HYDROXY COMPOUNDS
INFORMATION
ISOTOPES
KIDNEYS
LIGANDS
LIVER
MAMMALS
MATERIALS
MICE
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PHENOLS
PLUTONIUM 238
PLUTONIUM ISOTOPES
POLYPHENOLS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RODENTS
SKELETON
TISSUE DISTRIBUTION
URINE
VERTEBRATES
WASTES
YEARS LIVING RADIOISOTOPES