Specific sequestering agents for the actinides. 4. Removal of /sup 238/Pu(IV) from mice by sulfonated tetrameric catechoyl amides. [/sup 238/Pu]

Journal Article · Fri Feb 01 04:00:00 EST 1980 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575394· OSTI ID:5298862

Durbin, P W; Jones, E S; Raymond, K N; Weitl, F L

The similar chemical properties of Fe(III) and Pu(IV) - small ionic size, high charge, and high acidity - and the great stability of the complexes of Fe(III) with ligands secreted by microorganisms, specifically those containing the catechoyl (o-dihydroxybenzoic acid) functional group, suggested that tetracatechoyl ligands would be efficient in vivo sequestering agents for Pu(IV). Cyclic (CY) and linear (LI) tetracatechoyl amides (CAM) connected by ethylene, propylene, and/or butylene bridges were synthesized and administered intraperitoneally to mice (20 to 30 ..mu..mole/kg) 1 h after injection of about 1.5 ..mu..Ci/kg of /sup 238/Pu(IV) citrate. The mice were killed 24 h after the /sup 238/Pu injection, and the /sup 238/Pu in tissues and excreta was measured by using the L X rays. The prototype CAM ligand, 3,3,3,3-CYCAM, bound circulating /sup 238/Pu(IV), but the complex could not be excreted. Sulfonation of the benzene rings produced ligands (CAMS) that were soluble in water and stable to air oxidation. The linear 3,3,3-LICAMS was more efficient than its cyclic analog, 3,3,3,3-CYCAMS; /sup 238/Pu excretions were 44 and 35% of the injected dose, respectively. Lengthening the intergroup bridges to expand the metal coordination cavity (4,4,4-LICAMS or 3,4,3-LICAMS) increased /sup 238/Pu excretion to 65%; an equimolar amount of CaNa/sub 3/DTPA promoted 63% /sup 238/Pu excretion. The advantages of the CAMS ligands are: (a) low reactivity at pH 7 with divalent metals - their depletion is the cause of DTPA toxicity; (b) moderate toxicity - all CAM ligands except 4,4,4-LICAMS were tolerated by mice at the dosage administered; and (c) removal of some /sup 238/Pu already deposited in the skeleton - 3,4,3-LICAMS reduced skeletal /sup 238/Pu to 0.29 of the 1-h control value compared to a reduction to 0.56 by CaNa/sub 3/DTPA.

• Research Organization: Univ. of California, Berkeley
• OSTI ID: 5298862
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 81:2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

550600 -- Medicine
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMALS
CHELATING AGENTS
CLEANING
CLEARANCE
COMPLEXES
DECONTAMINATION
DISTRIBUTION
EVEN-EVEN NUCLEI
EXCRETION
HEAVY NUCLEI
IN VIVO
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
ISOTOPES
LIGANDS
MAMMALS
MICE
NUCLEI
PLUTONIUM 238
PLUTONIUM ISOTOPES
RADIOISOTOPES
RADIONUCLIDE KINETICS
RODENTS
TISSUE DISTRIBUTION
VERTEBRATES
YEARS LIVING RADIOISOTOPES