Specific sequestering agents for the actinides. 10. Enhancement of /sup 238/Pu elimination from mice by poly(catechoylamide) ligands

Journal Article · Sun Jul 01 04:00:00 EDT 1984 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576449· OSTI ID:6598949

Durbin, P W; Jeung, N; Jones, E S; Weitl, F L; Raymond, K N

Macromolecules containing four sulfonated catechoyl (2,3-dihydroxybenzoyl) groups are effective for decorporation of newly acquired Pu(IV). However, multiple injections in mice and single injections in dogs of 3,4,3-LICAM(S), the most effective sulfonated poly(catechoylamide) ligand, indicated that it would be toxic, so the ligand structure was modified. Each ligand was injected into mice 1 hr after an intravenous injection of /sup 238/Pu(IV) citrate, and mice were killed 24 hr after the Pu injection. Excreta and tissues were analyzed for Pu. (a) The number of catechoyl groups per molecule was reduced to suppress affinity for Fe(III). (b) A mesitylene platform was substituted for the linear backbone. (c) A carboxyl substituent on the catechoyl groups reduced the acidity and hydrophilicity of the ligands. (d) Large N-terminal alkane substituents added to 3,4,3-LICAM(C) increased ligand lipophilicity, hindered Pu chelation, and delayed excretion.

• Research Organization: Lawrence Berkeley Laboratory, CA
• DOE Contract Number: AC03-76SF00098
• OSTI ID: 6598949
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 99:1; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
AMINES
AMINO ACIDS
ANIMALS
AROMATICS
BODY
CARBOXYLIC ACID SALTS
CARBOXYLIC ACIDS
CATECHOLAMINES
CHELATING AGENTS
CITRATES
CLEARANCE
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
DTPA
EVEN-EVEN NUCLEI
EXCRETION
GLANDS
HEAVY NUCLEI
HYDROXY COMPOUNDS
ISOTOPES
LIGANDS
LIVER
MAMMALS
MICE
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PHENOLS
PLUTONIUM 238
PLUTONIUM ISOTOPES
POLYPHENOLS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RODENTS
SKELETON
TISSUE DISTRIBUTION
VERTEBRATES
YEARS LIVING RADIOISOTOPES