In vitro BALB/3T3 cell transformation assay of nonoxynol-9 and 1,4-dioxane

Journal Article · Fri Jan 01 04:00:00 EST 1988 · Environ. Mol. Mutagen.; (United States)

DOI:https://doi.org/10.1002/em.2850110106· OSTI ID:7024587

Sheu, C W; Moreland, F M; Lee, J K; Dunkel, V C

The spermicidal surfactant nonoxynol-9 (Igepal CO-630, GAF Corp.) and a potential impurity, 1,4-dioxane, were tested in the in vitro cell transformation assay using BALB/3T3 cells. Two treatment periods, 48 hr and 13 days, were used. Nonoxynol-9, tested at levels up to 10 /sup +/g/ml, did not induce transformation, whereas dioxane was very active in the induction type II foci in the cultured BALB/3T3 cells.

• Research Organization: Food and Drug Administration, Washington, DC (USA)
• OSTI ID: 7024587
• Journal Information: Environ. Mol. Mutagen.; (United States), Journal Name: Environ. Mol. Mutagen.; (United States) Vol. 11:1; ISSN ENMUE
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
CARCINOGENESIS
CELL TRANSFORMATIONS
CONNECTIVE TISSUE CELLS
DIOXANE
FIBROBLASTS
HETEROCYCLIC COMPOUNDS
IN VITRO
MAMMALS
MICE
ONCOGENIC TRANSFORMATIONS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PATHOGENESIS
RODENTS
SOMATIC CELLS
SURFACTANTS
VERTEBRATES