SCL (stem cell leukemia) gene, and a hematopoietic growth and differentiation factor encoded thereby
Patent
·
OSTI ID:7018995
A new human gene, SCL, was identified. The gene was discovered because of its involvement in a chromosomal translocation associated with the occurrence of a stem cell leukemia manifesting myeloid and lymphoid differentiation capabilities. The sequence of a cDNA for the normal SCL transcript is reported, as well as for an aberrant fusion transcript produced in the leukemic cells. Although different at their 3' untranslated regions, both cDNAs predict a protein within which is contained a region of primary amino acid sequence homology to the previously described amphipathic helix-loop-helix DNA binding and dimerization motif also contained within a variety of proteins whose role in development, differentiation, and proliferation has already been established.
- Research Organization:
- National Insts. of Health, Bethesda, MD (USA)
- Assignee:
- National Institutes of Health, Bethesda, MD
- Patent Number(s):
- A US 7-437819
- OSTI ID:
- 7018995
- Country of Publication:
- United States
- Language:
- English
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·
OSTI ID:5823175
Related Subjects
550200* -- Biochemistry
550400 -- Genetics
59 BASIC BIOLOGICAL SCIENCES
AMINO ACID SEQUENCE
ANIMAL CELLS
BODY
CELL DIFFERENTIATION
CHROMOSOMAL ABERRATIONS
DISEASES
DNA SEQUENCING
GENES
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
IMMUNE SYSTEM DISEASES
LEUKEMIA
MOLECULAR STRUCTURE
MUTATIONS
NEOPLASMS
PROTEIN STRUCTURE
SOMATIC CELLS
STEM CELLS
STRUCTURAL CHEMICAL ANALYSIS
550400 -- Genetics
59 BASIC BIOLOGICAL SCIENCES
AMINO ACID SEQUENCE
ANIMAL CELLS
BODY
CELL DIFFERENTIATION
CHROMOSOMAL ABERRATIONS
DISEASES
DNA SEQUENCING
GENES
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
IMMUNE SYSTEM DISEASES
LEUKEMIA
MOLECULAR STRUCTURE
MUTATIONS
NEOPLASMS
PROTEIN STRUCTURE
SOMATIC CELLS
STEM CELLS
STRUCTURAL CHEMICAL ANALYSIS