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Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias

Journal Article · · Proceedings of the National Academy of Sciences of the United States of America; (United States)
; ; ; ; ; ; ; ; ; ;  [1]
  1. Univ. of Chicago, IL (United States)
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Recurring chromosomal translocations involving chromosome 11, band q23, have been observed in acute lymphoid leukemias and especially in acute myeloid leukemias. The authors recently showed that breakpoints in four 11q23 translocations, t(4,11)(q21;q23), t(6;11)(q27;q23), t(9;11)(p22;q23), and t(11;19)(q23;p13.3), were contained within a yeast artificial chromosome clone bearing the CD3D and CD3G gene loci. They have identified within the CD3 yeast artificial chromosome a transcription unit that spans the breakpoint junctions of the 4;11, 9;11, and 11;19 translocations, and they describe two other, related transcripts that are upregulated in the RS4;11 cell line. They have named this gene MLL (myeloid/lymphoid, or mixed-lineage, leukemia).

OSTI ID:
5823175
Journal Information:
Proceedings of the National Academy of Sciences of the United States of America; (United States), Journal Name: Proceedings of the National Academy of Sciences of the United States of America; (United States) Vol. 88:23; ISSN PNASA; ISSN 0027-8424
Country of Publication:
United States
Language:
English

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Related Subjects

550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARCINOGENS
CHROMOSOMAL ABERRATIONS
CHROMOSOMES
DAYS LIVING RADIOISOTOPES
DISEASES
DNA HYBRIDIZATION
DNA SEQUENCING
ESTERS
FETAL MEMBRANES
FLUORESCENCE
GENES
GENETIC MAPPING
HETEROCHROMOSOMES
HYBRIDIZATION
IMMUNE SYSTEM DISEASES
ISOTOPES
LEUKEMIA
LIGHT NUCLEI
LUMINESCENCE
MAPPING
MEMBRANES
MUTATIONS
NEOPLASMS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PHORBOL ESTERS
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
PLACENTA
RADIOISOTOPES
STRUCTURAL CHEMICAL ANALYSIS
TRANSLOCATION