Percutaneous absorption of (7. 10-/sup 14/C)benzo(a)pyrene and (7,12-/sup 14/C)dimethylbenz(a)anthracene in mice
Journal Article
·
· Environ. Res.; (United States)
OSTI ID:7012191
The percutaneous penetration, tissue distribution, and excretion of /sup 14/C-labeled benzo(a)pyrene (BaP) and dimethylbenz(a)anthracene (DMBA) were studied in mice. Both BaP and DMBA rapidly penetrated the skin and were excreted more in the feces than in the urine. The proportion of BaP or DMBA absorbed was less with increasing applied dose due to apparent saturation of the uptake process. Uptake from the dorsal skin of the nose was similar to uptake from the dorsal nuchal skin. 24 references.
- Research Organization:
- Pacific Northwest Lab., Richland, WA
- DOE Contract Number:
- AC06-76RL01830
- OSTI ID:
- 7012191
- Journal Information:
- Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 33:2; ISSN ENVRA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ANIMALS
AROMATICS
BENZANTHRACENE
BENZOPYRENE
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CARBON 14 COMPOUNDS
CLEARANCE
CONDENSED AROMATICS
DOSE-RESPONSE RELATIONSHIPS
EXCRETION
FECES
HYDROCARBONS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
MICE
ORGANIC COMPOUNDS
RODENTS
SKIN ABSORPTION
UPTAKE
URINE
VERTEBRATES
WASTES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ANIMALS
AROMATICS
BENZANTHRACENE
BENZOPYRENE
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CARBON 14 COMPOUNDS
CLEARANCE
CONDENSED AROMATICS
DOSE-RESPONSE RELATIONSHIPS
EXCRETION
FECES
HYDROCARBONS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
MICE
ORGANIC COMPOUNDS
RODENTS
SKIN ABSORPTION
UPTAKE
URINE
VERTEBRATES
WASTES