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Embryotoxic effects of benzo(. cap alpha. )pyrene, chrysene, and 7,12-dimethylbenz(. cap alpha. )anthracene in petroleum hydrocarbon mixtures in mallard ducks

Journal Article · · J. Toxicol. Environ. Health; (United States)
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In the present study the effects of three polycyclic aromatic hydrocarbons identified in petroleum were examined on mallard (Anas platyrhynchos) embryo development. Addition of benzo(a)pyrene (BaP), chrysene, or 7,12-dimethylbenz(a)anthracene (DMBA) to a synthetic petroleum hydrocarbon mixture of known composition and relatively low embryotoxicity resulted in embryotoxicity that was enhanced or equal to that of crude oil when 10 ..mu../ was applied externally to eggs at 72 h of development. The order of ability to enhance embryotoxicity was DMBA > BaP > chrysene. The temporal pattern of embryonic death was similar to that reported after exposure to crude oil. Retarded growth was accompanied by teratogenicity. Gas chromatographic-mass spectral analysis of externally treated eggs showed the passage of aromatic hydrocarbons including chrysene through the shell and shell membranes to the developing embryos. These findings suggest that the presence of polycyclic aromatic hydrocarbons in petroleum, including BaP, chrysene, and DMBA, significantly enhances the overall embryotoxicity in avian species.

Research Organization:
Fish and Wildlife Service, Laurel, MD
OSTI ID:
6453582
Journal Information:
J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 7:5; ISSN JTEHD
Country of Publication:
United States
Language:
English

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Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BENZOPYRENE
BIOLOGICAL EFFECTS
BIRDS
CHROMATOGRAPHY
CHRYSENE
CONDENSED AROMATICS
CONGENITAL MALFORMATIONS
DIMETHYLBENZANTHRACENE
DUCKS
EGGS
EMBRYOS
ENERGY SOURCES
FOSSIL FUELS
FOWL
FUELS
GAS CHROMATOGRAPHY
HATCHING
HYDROCARBONS
MALFORMATIONS
MASS SPECTROSCOPY
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
PETROLEUM
SEPARATION PROCESSES
SPECTROSCOPY
SYNERGISM
VERTEBRATES