Cadmium-induced alterations in the antioxidant defense system of the rat eye in relation to dietary selenium intake

Thesis/Dissertation · Sun Jan 01 04:00:00 EST 1989

OSTI ID:7001033

Sinno, J A.M.

Studies were conducted to investigate the effects of dietary cadmium (Cd)upon enzymatic antioxidant function in the ocular tissues of the albino rat. Activity of glutathione peroxidase (GSH-Px), Se-independent GSH-Px and catalase, and concentrations of thiobarbituric acid-reactive substances (TBARS), glutathione, and the elements Se, Cd and copper (Cu) were determined in ocular tissues from each group. Feeding rats a low Se diet resulted in a significant decrease in GSH-Px activity irrespective of Cd treatment. Activity of Se-independent GSH-Px in rats maintained on the low Se diet decreased when compared to Se-adequate controls. Cd treatment of rats fed low Se resulted in increased activity when compared to low-Se controls. When comparisons were made between ocular TBARS in rats maintained at either level of dietary Se, with or without Cd treatment, decreased ocular TBARS were observed in Cd-treated groups. A significant decrease in the ocular concentration of Se occurred in rats fed 0.05 ppm Se when compared to rats supplemented with 0.10 ppm Se. Administering Cd to the low Se group increased ocular Se levels 100%. A negative correlation between ocular Se concentration and the level of TBARS was observed, suggesting a possible alternate role for Se as an antioxidant in the eye.

• Research Organization: Saint John's Univ., Jamaica, NY (USA)
• OSTI ID: 7001033
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIOXIDANTS
BIOLOGICAL EFFECTS
BODY
BODY AREAS
CADMIUM
DIET
ELEMENTS
ENZYME ACTIVITY
ENZYMES
EYES
FACE
HEAD
MAMMALS
METALS
ORGANS
OXIDOREDUCTASES
PEROXIDASES
RATS
RODENTS
SENSE ORGANS
SENSITIVITY
TOXICITY
VERTEBRATES