Cadmium-induced alterations in the antioxidant defense system of the rat eye in relation to dietary selenium intake
Studies were conducted to investigate the effects of dietary cadmium (Cd)upon enzymatic antioxidant function in the ocular tissues of the albino rat. Activity of glutathione peroxidase (GSH-Px), Se-independent GSH-Px and catalase, and concentrations of thiobarbituric acid-reactive substances (TBARS), glutathione, and the elements Se, Cd and copper (Cu) were determined in ocular tissues from each group. Feeding rats a low Se diet resulted in a significant decrease in GSH-Px activity irrespective of Cd treatment. Activity of Se-independent GSH-Px in rats maintained on the low Se diet decreased when compared to Se-adequate controls. Cd treatment of rats fed low Se resulted in increased activity when compared to low-Se controls. When comparisons were made between ocular TBARS in rats maintained at either level of dietary Se, with or without Cd treatment, decreased ocular TBARS were observed in Cd-treated groups. A significant decrease in the ocular concentration of Se occurred in rats fed 0.05 ppm Se when compared to rats supplemented with 0.10 ppm Se. Administering Cd to the low Se group increased ocular Se levels 100%. A negative correlation between ocular Se concentration and the level of TBARS was observed, suggesting a possible alternate role for Se as an antioxidant in the eye.
- Research Organization:
- Saint John's Univ., Jamaica, NY (USA)
- OSTI ID:
- 7001033
- Resource Relation:
- Other Information: Thesis (Ph. D.)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CADMIUM
TOXICITY
EYES
SENSITIVITY
PEROXIDASES
ENZYME ACTIVITY
ANTIOXIDANTS
BIOLOGICAL EFFECTS
DIET
RATS
ANIMALS
BODY
BODY AREAS
ELEMENTS
ENZYMES
FACE
HEAD
MAMMALS
METALS
ORGANS
OXIDOREDUCTASES
RODENTS
SENSE ORGANS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology