Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Effect of selenium supplementation on the level of glutathione-peroxidase (GSH-Px) activity in the nursing rat

Conference · · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
OSTI ID:5493151
; ; ; ;
Prevention of retinopathy of prematurity using vitamin E as an antioxidant has been demonstrated. The purpose of this experiment was to study the antioxidant system, GSH-Px, (a selenoenzyme), in the retina. The effect of i.p. administration and dietary Se as selenite or selenomethionine (selmet) on tissue GSH-Px activity was determined in nursing pups. Dams were randomized into 3 dietary treatments (Basal, 0.15 ppm selenite, and 0.15 ppm selmet) and mated. Pups were sacrificed at 0, 7, and 14 days after delivery and GSH-Px was measured in pup eyes, hearts, livers, and kidneys, and dam livers. The pups of the dams consuming the Basal diet were divided into 4 i.p. groups: none, saline, selenite, and selmet (3 ..mu..g Se/kg body wt). The i.p. Se had no effect on GSH-Px activity in eye or heart, but significantly increased GSH-Px activity in liver and kidney with no difference between selenite and selmet. The pups of the dams consuming selenite and selmet diets showed significantly higher GSH-Px activity in all tissues studied than those consuming the Basal diet. For all tissues GSH-Px activity was higher for pups and dams fed selmet than those fed selenite. This research demonstrates that there was a difference in selenium availability between diet and i.p. administration.
Research Organization:
Auburn Univ., AL
OSTI ID:
5493151
Report Number(s):
CONF-8604222-
Conference Information:
Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:3
Country of Publication:
United States
Language:
English

Similar Records

Bioavailability of seleno-compounds in the lactating rat
Conference · Fri Feb 28 23:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) · OSTI ID:5321458
Cadmium-induced alterations in the antioxidant defense system of the rat eye in relation to dietary selenium intake
Thesis/Dissertation · Sat Dec 31 23:00:00 EST 1988 · OSTI ID:7001033
Effect of selenium and omega-3 fatty acids on selected risk factors for heart disease
Conference · Fri Feb 28 23:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) · OSTI ID:5430853

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
BODY AREAS
CARDIOVASCULAR SYSTEM
DIGESTIVE SYSTEM
ELEMENTS
ENZYME ACTIVITY
ENZYMES
EYES
FACE
GLANDS
HEAD
HEART
KIDNEYS
LACTATION
LIVER
MAMMALS
ORGANS
OXIDOREDUCTASES
PEROXIDASES
RATS
RETINA
RODENTS
SELENIUM
SEMIMETALS
SENSE ORGANS
VERTEBRATES
VITAMIN E
VITAMINS