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Effect of selenium and omega-3 fatty acids on selected risk factors for heart disease

Conference · · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
OSTI ID:5430853
; ;

Male weanling Sprague-Dawley rats were fed for 6 months a Torula yeast basal diet supplemented with one of three levels of Selenium (Se) (0, 0.1, or 1.0 ppm as Na/sub 2/-SeO/sub 3/), with or without a marine oil supplement (MaxEPA, Seven Seas, Hull, Eng.) added at 5% in a 3 x 2 factorial design. Dependent variables measured included: liver and platelet Se-glutathione peroxidase, (Se-GSH-Px); weight gain; relative weights (percent of body weight) of heart and a standardized section of aorta; and ADP-induced platelet aggregation. Dietary Se supplementation increased weight gain, liver and platelet Se-GSH-Px, and decreased relative heart and aorta weight (p < .001). MaxEPA significantly decreased platelet Se-GSH-Px (p < .05). Histological examination showed focal disruption of elastic fibers in aortic segments from rats fed the following diets: 0 Se without MaxEPA, 0 Se with MaxEPA, and 0.1 Se with MaxEPA. There were no significant differences in platelet aggregation among dietary groups. These findings suggest the following: (1) Se may be required for maintenance of normal integrity of the elastic tissue of the aortic wall; (2) high levels of polyunsaturates in the diet may compromise the protective effect of Se on elastic fibers in the aortic wall.

Research Organization:
Brigham Young Univ., Provo, UT
OSTI ID:
5430853
Report Number(s):
CONF-8604222-
Journal Information:
Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Vol. 45:3; ISSN FEPRA
Country of Publication:
United States
Language:
English

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Related Subjects

550900 -- Pathology
560305* -- Chemicals Metabolism &amp; Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD COAGULATION
BLOOD PLATELETS
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
DIGESTIVE SYSTEM
DISEASES
ELEMENTS
ENZYMES
GLANDS
LIVER
MAMMALS
MATERIALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
PEROXIDASES
RATS
RISK ASSESSMENT
RODENTS
SELENIUM
SEMIMETALS
VERTEBRATES
WEIGHT