Effects of tocopherol and selenium supplementation on vitamin A evaluated by response surface analysis

Conference · Fri Mar 15 04:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5174008

Stoecker, B J; Seaborn, C D; Kiangura, R K; Hermann, J R ^[1]

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1. Oklahoma State Univ., Stillwater (United States)

Sixty-six weanling male rats were fed torula-yeast based diets and deprived of selenium, vitamin A and tocopherol for five weeks. Subsequently a two-factor central composite response surface experimental design was used to determine Se and tocopherol supplementation for nine groups. Selenium, as sodium selenate, was added to the diets at concentrations between 0 and 1.0 ppm. Rats were dosed with 0.2 to 50 mg/day of dl-alpha-tocopherol. All animals were fed 100 ug beta-carotene daily. Body, liver, and spleen weights were not significantly affecteds ofdietary treatments. Dietary Se affected heart weight. Hepatic vitamin A decreased linearly with increasing tocopherol supplements. In the combinations used, tocopherol decreased total vitamin A in liver and kidney but did not interact significantly with Se.

• OSTI ID: 5174008
• Report Number(s): CONF-9104107--
• Conference Information: Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States) Journal Volume: 5:5
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BODY
DIET
DIGESTIVE SYSTEM
ELEMENTS
GLANDS
LIVER
MAMMALS
ORGANS
RATS
RODENTS
SELENIUM
SEMIMETALS
SYNTHESIS
VERTEBRATES
VITAMIN A
VITAMIN E
VITAMINS