Effects of copper and selenium on beta-carotene conversion and bone strength in rats

Conference · Thu Mar 14 23:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5144342

Seaborn, C D; Kiangura, R K; Brusewitz, G H; Stoecker, B J ^[1]

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1. Oklahoma State Univ., Stillwater (United States)

Thirty-four weanling male rats were depleted of vitamin A and selenium for 5 wk, randomly assigned to groups in a 2 {times} 2 factorial design, and fed a torula yeast diet without vitamin A for 4 wks. The diets contained either 20 ppb Se ({minus}Se) or 510 ppb Se as sodium selenate (+Se) and 1 ppm Cu ({minus}Cu) or 6 ppm Cu (+Cu). Rats were fed 100 ug of beta-carotene daily. Force to break tibias was measured with a three point bending fixture in an Instron universal testing machine. Bone weights and kg force to break bones were increased by +Cu diets. Animals fed the {minus}Cu diets had depressed body and organ weights. An interaction between Cu and Se affected hepatic and kidney vitamin A after feeding carotene. Total hepatic vitamin A was 26.8, 44.2, 45.1 and 32.5 ug for the {minus}Cu{minus}Se, {minus}Cu+Se, +Cu{minus}Se, and +Cu+Se groups, respectively. Total kidney vitamin A was 8.7, 3.9, 7.1 and 13.5 ug for the same groups. Beta-carotene dioxygenase activity was not significantly affected by treatment. The findings indicate that dietary Cu and Se affect the metabolism of vitamin A.

• OSTI ID: 5144342
• Report Number(s): CONF-9104107--
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States) Vol. 5:5; ISSN 0892-6638; ISSN FAJOE
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
COPPER
ELEMENTS
ENZYME ACTIVITY
ENZYMES
MAMMALS
METABOLISM
METALS
NUTRITIONAL DEFICIENCY
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
OXYGENASES
PROTEINS
RATS
RODENTS
SELENIUM
SEMIMETALS
SKELETON
TRANSITION ELEMENTS
VERTEBRATES
VITAMIN A
VITAMINS