Deuterium oxide normalizes blood pressure and vascular calcium uptake in Dahl salt-sensitive hypertensive rats

Journal Article · Thu Feb 01 04:00:00 EST 1990 · Hypertension (Dallas); (USA)

DOI:https://doi.org/10.1161/01.HYP.15.2.183· OSTI ID:6992080

Vasdev, S; Prabhakaran, V; Sampson, C A ^[1]

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1. General Hospital, St. John's, Newfoundland (Canada)

This study examined the effect of 25% deuterium oxide in drinking water on systolic blood pressure, uptakes of calcium, and rubidium 86 by aortas of Dahl salt-sensitive rats on 0.4% (low) and 8% (high) sodium chloride (salt) diet. Twenty-four rats were divided into four groups. Groups I and II were on the low salt diet and groups III and IV on the high salt diet from 6 weeks of age. Additionally, at 10 weeks of age groups I and III were placed on 100% water and groups II and IV on 25% deuterium oxide. At 14 weeks, systolic blood pressure, uptakes of calcium, and rubidium 86 by aortas were significantly higher (p less than 0.01) in rats on the high salt diet as compared with those on the low salt diet. Deuterium oxide intake normalized systolic blood pressure and aortic calcium uptake but not aortic rubidium 86 uptake in hypertensive rats on the high salt diet. Deuterium oxide had no effect on blood pressure or aortic calcium uptake in rats on the low salt diet. The parallel increase in systolic blood pressure and vascular calcium uptake suggests that increased calcium uptake mechanisms are associated with hypertension in salt-sensitive Dahl rats. Furthermore, deuterium oxide appears to normalize elevated blood pressure in salt-sensitive hypertensive rats by normalizing elevated vascular (aortic) calcium uptake.

• OSTI ID: 6992080
• Journal Information: Hypertension (Dallas); (USA), Journal Name: Hypertension (Dallas); (USA) Vol. 15:2; ISSN 0194-911X; ISSN HPRTD
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACID ANHYDRASES
ALKALI METAL COMPOUNDS
ALKALI METAL ISOTOPES
ALKALINE EARTH METALS
ANIMALS
AORTA
ARTERIES
ATP-ASE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BLOOD PRESSURE
BLOOD VESSELS
BODY
CALCIUM
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHLORIDES
CHLORINE COMPOUNDS
DAYS LIVING RADIOISOTOPES
DEUTERIUM
DISEASES
ELEMENTS
ENZYMES
HALIDES
HALOGEN COMPOUNDS
HYDROGEN ISOTOPES
HYDROLASES
HYPERTENSION
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LIGHT NUCLEI
MAMMALS
METALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANS
PATHOGENESIS
PHOSPHOHYDROLASES
RADIOISOTOPES
RATS
RODENTS
RUBIDIUM 86
RUBIDIUM ISOTOPES
SODIUM CHLORIDES
SODIUM COMPOUNDS
STABLE ISOTOPES
SYMPTOMS
UPTAKE
VASCULAR DISEASES
VERTEBRATES