Elevated sup 22 Na uptake in aortae of Dahl salt-sensitive rats with high salt diet

Journal Article · Mon Jan 01 04:00:00 EST 1990 · Artery (Fulton, Michigan); (USA)

OSTI ID:6068737

Vasdev, S; Prabhakaran, V; Sampson, C A ^[1]

---

1. General Hospital, St. John's, Noufoundland (Canada)

We examined the effects of high salt intake on blood pressure and vascular {sup 22}Na uptake in Dahl salt-sensitive (DS) rats. At 6 weeks of age, one group of 6 DS rats was placed on a low (0.4%) salt diet and the second group of 6 DS rats was placed on a high (8.0%) salt diet for a period of 4 weeks. Blood pressure recordings were made weekly. At 10 weeks of age, the animals were sacrificed and aortic {sup 22}Na uptake was measured. Total and amiloride sensitive (Na(+)-H+ antiport) components of {sup 22}Na uptake were measured from which was calculated the amiloride insensitive component. Na+, K(+)-pumps were inhibited for these vascular {sup 22}Na uptake experiments with ouabain to prevent Na+ efflux. DS rats on the high salt diet demonstrated significantly (P less than 0.01) higher blood pressure when compared to DS rats on a low salt diet. Similarly, DS rats on a high salt diet demonstrated significantly (P less than 0.05) higher total, amiloride sensitive and amiloride insensitive vascular {sup 22}Na uptake as compared to DS rats on low salt diet. The parallel increase in vascular {sup 22}Na uptake and blood pressure suggests a possible, key role of Na+ influx in the mechanism of salt induced hypertension of DS rats.

• OSTI ID: 6068737
• Journal Information: Artery (Fulton, Michigan); (USA), Journal Name: Artery (Fulton, Michigan); (USA) Vol. 17:6; ISSN 0098-6127; ISSN ARTED
• Country of Publication: United States
• Language: English

Related Subjects

550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALKALI METAL COMPOUNDS
ALKALI METAL ISOTOPES
ANIMALS
AORTA
ARTERIES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BLOOD PRESSURE
BLOOD VESSELS
BODY
CARBOHYDRATES
CARDIAC GLYCOSIDES
CARDIOTONICS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHLORIDES
CHLORINE COMPOUNDS
DIET
DISEASES
DRUGS
GLYCOSIDES
HALIDES
HALOGEN COMPOUNDS
HYPERTENSION
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MAMMALS
MEMBRANE TRANSPORT
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
OUABAIN
PATHOGENESIS
RADIOISOTOPES
RATS
RODENTS
SODIUM 22
SODIUM CHLORIDES
SODIUM COMPOUNDS
SODIUM ISOTOPES
STROPHANTHINS
SYMPTOMS
TRACER TECHNIQUES
VASCULAR DISEASES
VERTEBRATES
YEARS LIVING RADIOISOTOPES