Influence of cadmium on salt-induced hypertension in Dahl hypertension-sensitive rats
Conference
·
OSTI ID:6741033
This study investigated the influence of cadmium (Cd) on the pathogenesis of salt-induced hypertension in Dahl hypertension-sensitive (S) rats bred for susceptibility to the hypertensive effect of excess dietary salt (NaCl). Weanling female S rats were divided into two groups. The rats in the Cd group received 2 mg Cd/kg ip on week 3 (3 weeks of age) followed by 2nd and 3rd injections of 1 mg Cd/kg on weeks 6 and 23. The controls received the same volume of 0.9% aqueous NaCl ip. A high salt (4% NaCl) diet and tap water were available ad libitum. Cd enhanced the rate and the degree at which salt-induced hypertension developed (week 7), leading to an accelerated phase (week 24) associated with a mean systolic blood pressure of 245 mm Hg and drastically increased morbidity and mortality. Conversely, the hypertensive process in the controls averaging a blood pressure of 207 mm Hg was not heralded by other discernible toxic manifestations. Pathological lesions of periarteritis nodosa in the mesenteric arteries and nephrosclerosis occurred to the same extent in the Cd and control groups. This study demonstrated that Cd exacerbated the severity of salt-induced hypertension in S rats.
- Research Organization:
- Brookhaven National Lab., Upton, N.Y. (USA)
- DOE Contract Number:
- EY-76-C-02-0016
- OSTI ID:
- 6741033
- Report Number(s):
- BNL-24337; CONF-780631-1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
551000 -- Physiological Systems
560400* -- Other Environmental Pollutant Effects
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL COMPOUNDS
ANIMALS
BIOLOGICAL EFFECTS
BLOOD PRESSURE
CADMIUM
CARDIOVASCULAR DISEASES
CHLORIDES
CHLORINE COMPOUNDS
DIET
DISEASES
ELEMENTS
HALIDES
HALOGEN COMPOUNDS
HYPERTENSION
MAMMALS
METALS
MORTALITY
PATHOLOGICAL CHANGES
RATS
RODENTS
SENSITIVITY
SODIUM CHLORIDES
SODIUM COMPOUNDS
SYMPTOMS
SYNERGISM
VASCULAR DISEASES
VERTEBRATES
560400* -- Other Environmental Pollutant Effects
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL COMPOUNDS
ANIMALS
BIOLOGICAL EFFECTS
BLOOD PRESSURE
CADMIUM
CARDIOVASCULAR DISEASES
CHLORIDES
CHLORINE COMPOUNDS
DIET
DISEASES
ELEMENTS
HALIDES
HALOGEN COMPOUNDS
HYPERTENSION
MAMMALS
METALS
MORTALITY
PATHOLOGICAL CHANGES
RATS
RODENTS
SENSITIVITY
SODIUM CHLORIDES
SODIUM COMPOUNDS
SYMPTOMS
SYNERGISM
VASCULAR DISEASES
VERTEBRATES