Etiological role of cadmium in hypertension in an animal model. [Rats]

Journal Article · Tue Jan 01 04:00:00 EST 1980 · J. Environ. Pathol. Toxicol.; (United States)

OSTI ID:6354422

Ohanian, E V; Iwai, J

Dahl hypertension-resistant (R) and hypertension-sensitive (S) lines of rats were used to determine whether cadmium plays an etiological role in hypertension. In Study I, weanling R and S rats of both sexes were given a low-salt diet and were divided into two groups. Rats in the cadmium group were injected with cadmium, whereas the controls received identical volumes of saline. Three weeks after the first injection, no elevations of systolic blood pressure were detected. A second dose of cadmium (1 mg/kg) produced hypertension in S females but not in S males or in R rats of either sex. In Study II, weanling female S rats on a high-salt diet were given cadmium (2 mg/kg body weight, ip) at week 3 followed by second and third injections of cadmium (1 mg/kg) at weeks 6 and 23. Cadmium enhanced the rate and the degree of salt-induced hypertension development. These data indicate that differences in genetic background influence the development of cadmium-induced hypertension in weanling rats, and that cadmium exacerbates the severity of salt-induced hypertension.

• Research Organization: Brookhaven National Lab., Upton, NY
• DOE Contract Number: EY-76-C-02-0016
• OSTI ID: 6354422
• Journal Information: J. Environ. Pathol. Toxicol.; (United States), Journal Name: J. Environ. Pathol. Toxicol.; (United States) Vol. 4:2,3; ISSN JEPTD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL VARIABILITY
BLOOD PRESSURE
BODY
CADMIUM
CARDIOVASCULAR DISEASES
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
ELEMENTS
ETIOLOGY
GENETIC VARIABILITY
GLANDS
HYPERTENSION
KIDNEYS
LIVER
MAMMALS
METALS
ORGANS
RATS
RODENTS
SYMPTOMS
TISSUE DISTRIBUTION
VASCULAR DISEASES
VERTEBRATES