Genetic influence on hypertension induced by cadmium in Dahl hypertension-resistant and hypertension-sensitive rats
Conference
·
OSTI ID:7353056
Dahl hypertension-resistant (R) and hypertension-sensitive (S) rats, with opposite genetically controlled propensities for hypertension, were used to determine if cadmium-induced hypertension was also dependent upon genetic predisposition. When intraperitoneal injections of cadmium (1 and 2 mg/kg) were given to male and female R and S rats maintained under ordinary laboratory conditions, female S rats manifested a significant increase in blood pressure which persisted for 16 weeks, whereas the R rats and the male S rats showed no significant changes in blood pressure. Cadmium had no effect on body weight. The concentrations of cadmium in hepatic and renal tissues of cadmium-injected male and female S rats were significantly higher than that of R rats. The kidneys of female S rats given cadmium showed renal vascular changes in accord with renal hypertension of moderate degree. We concluded that differences in genetic substrate influence the pathogenesis of experimental cadmium-induced hypertension.
- Research Organization:
- Brookhaven National Lab., Upton, N.Y. (USA)
- Sponsoring Organization:
- US Energy Research and Development Administration (ERDA)
- DOE Contract Number:
- E(30-1)-16
- OSTI ID:
- 7353056
- Report Number(s):
- BNL-21463; CONF-760632-3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550900 -- Pathology
550901* -- Pathology-- Tracer Techniques
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BLOOD VESSELS
BODY
CADMIUM
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
ELEMENTS
ETIOLOGY
FEMALES
GENETIC CONTROL
GLANDS
HYPERTENSION
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
KIDNEYS
LIVER
MALES
MAMMALS
METALS
ORGANS
PATHOLOGICAL CHANGES
PEST CONTROL
RATS
RODENTS
SYMPTOMS
TISSUE DISTRIBUTION
VASCULAR DISEASES
VERTEBRATES
550901* -- Pathology-- Tracer Techniques
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BLOOD VESSELS
BODY
CADMIUM
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
ELEMENTS
ETIOLOGY
FEMALES
GENETIC CONTROL
GLANDS
HYPERTENSION
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
KIDNEYS
LIVER
MALES
MAMMALS
METALS
ORGANS
PATHOLOGICAL CHANGES
PEST CONTROL
RATS
RODENTS
SYMPTOMS
TISSUE DISTRIBUTION
VASCULAR DISEASES
VERTEBRATES